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296 results

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Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes.
Meeks KAC, Bentley AR, Assimes TL, Franceschini N, Adeyemo AA, Rotimi CN, Doumatey AP. Meeks KAC, et al. Among authors: assimes tl. Genome Med. 2023 Dec 4;15(1):108. doi: 10.1186/s13073-023-01263-7. Genome Med. 2023. PMID: 38049854 Free PMC article.
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV, Hofman A, Karssen LC, Struchalin M, Floyd J, Igl W, Biloglav Z, Broer L, Pfeufer A, Pichler I, Campbell S, Zaboli G, Kolcic I, Rivadeneira F, Huffman J, Hastie ND, Uitterlinden A, Franke L, Franklin CS, Vitart V; DIAGRAM Consortium; Nelson CP, Preuss M; CARDIoGRAM Consortium; Bis JC, O'Donnell CJ, Franceschini N; CHARGE Consortium; Witteman JC, Axenovich T, Oostra BA, Meitinger T, Hicks AA, Hayward C, Wright AF, Gyllensten U, Campbell H, Schmitz G; EUROSPAN consortium. Demirkan A, et al. PLoS Genet. 2012;8(2):e1002490. doi: 10.1371/journal.pgen.1002490. Epub 2012 Feb 16. PLoS Genet. 2012. PMID: 22359512 Free PMC article.
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study.
Chan WC, Liu L, Bouras E, Zuber V, Wen W, Long J, Gill D, Murphy N, Gunter MJ, Assimes TL, Bujanda L, Gruber SB, Küry S, Lynch BM, Qu C, Thomas M, White E, Woods MO, Peters U, Li CI, Chan AT, Brenner H, Tsilidis KK, Zheng W. Chan WC, et al. Among authors: assimes tl. Br J Cancer. 2024 Nov 23. doi: 10.1038/s41416-024-02900-7. Online ahead of print. Br J Cancer. 2024. PMID: 39580580
Plasma proteomics and carotid intima-media thickness in the UK biobank cohort.
Chen ML, Kho PF, Guarischi-Sousa R, Zhou J, Panyard DJ, Azizi Z, Gupte T, Watson K, Abbasi F, Assimes TL. Chen ML, et al. Among authors: assimes tl. Front Cardiovasc Med. 2024 Oct 2;11:1478600. doi: 10.3389/fcvm.2024.1478600. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 39416432 Free PMC article.
Rare variant contribution to the heritability of coronary artery disease.
Rocheleau G, Clarke SL, Auguste G, Hasbani NR, Morrison AC, Heath AS, Bielak LF, Iyer KR, Young EP, Stitziel NO, Jun G, Laurie C, Broome JG, Khan AT, Arnett DK, Becker LC, Bis JC, Boerwinkle E, Bowden DW, Carson AP, Ellinor PT, Fornage M, Franceschini N, Freedman BI, Heard-Costa NL, Hou L, Chen YI, Kenny EE, Kooperberg C, Kral BG, Loos RJF, Lutz SM, Manson JE, Martin LW, Mitchell BD, Nassir R, Palmer ND, Post WS, Preuss MH, Psaty BM, Raffield LM, Regan EA, Rich SS, Smith JA, Taylor KD, Yanek LR, Young KA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Hilliard AT, Tcheandjieu C, Peyser PA, Vasan RS, Rotter JI, Miller CL, Assimes TL, de Vries PS, Do R. Rocheleau G, et al. Among authors: assimes tl. Nat Commun. 2024 Oct 9;15(1):8741. doi: 10.1038/s41467-024-52939-6. Nat Commun. 2024. PMID: 39384761 Free PMC article.
Exome wide association study for blood lipids in 1,158,017 individuals from diverse populations.
Koyama S, Yu Z, Choi SH, Jurgens SJ, Selvaraj MS, Klarin D, Huffman JE, Clarke SL, Trinh MN, Ravi A, Dron JS, Spinks C, Surakka I, Bhatnagar A, Lannery K, Hornsby W, Damrauer SM, Chang KM, Lynch JA, Assimes TL, Tsao PS, Rader DJ, Cho K, Peloso GM, Ellinor PT, Sun YV, Wilson PW, Program MV, Natarajan P. Koyama S, et al. Among authors: assimes tl. medRxiv [Preprint]. 2024 Sep 18:2024.09.17.24313718. doi: 10.1101/2024.09.17.24313718. medRxiv. 2024. PMID: 39371182 Free PMC article. Preprint.
A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances.
Noordam R, Wang W, Nagarajan P, Wang H, Brown MR, Bentley AR, Hui Q, Kraja AT, Morrison JL, O'Connel JR, Lee S, Schwander K, Bartz TM, de las Fuentes L, Feitosa MF, Guo X, Hanfei X, Harris SE, Huang Z, Kals M, Lefevre C, Mangino M, Milaneschi Y, van der Most P, Pacheco NL, Palmer ND, Rao V, Rauramaa R, Sun Q, Tabara Y, Vojinovic D, Wang Y, Weiss S, Yang Q, Zhao W, Zhu W, Abu Yusuf Ansari M, Aschard H, Anugu P, Assimes TL, Attia J, Baker LD, Ballantyne C, Bazzano L, Boerwinkle E, Cade B, Chen HH, Chen W, Ida Chen YD, Chen Z, Cho K, De Anda-Duran I, Dimitrov L, Do A, Edwards T, Faquih T, Hingorani A, Fisher-Hoch SP, Gaziano JM, Gharib SA, Giri A, Ghanbari M, Grabe HJ, Graff M, Gu CC, He J, Heikkinen S, Hixson J, Ho YL, Hood MM, Houghton SC, Karvonen-Gutierrez CA, Kawaguchi T, Kilpeläinen TO, Komulainen P, Lin HJ, Linchangco GV, Luik AI, Ma J, Meigs JB, McCormick JB, Menni C, Nolte IM, Norris JM, Petty LE, Polikowsky HG, Raffield LM, Rich SS, Riha RL, Russ TC, Ruiz-Narvaez EA, Sitlani CM, Smith JA, Snieder H, Sofer T, Shen B, Tang J, Taylor KD, Teder-Laving M, Triatin R, Tsai MY, Völzke H, Westerman KE, Xia R, Yao J, Young KL, Zhang R, Zonderman AB, Zhu X, Below JE, Cox SR, Ev… See abstract for full author list ➔ Noordam R, et al. Among authors: assimes tl. medRxiv [Preprint]. 2024 Sep 4:2024.09.02.24312466. doi: 10.1101/2024.09.02.24312466. medRxiv. 2024. PMID: 39281768 Free PMC article. Preprint.
296 results