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A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques.
Smith AA, Su H, Wallach J, Liu Y, Maiello P, Borish HJ, Winchell C, Simonson AW, Lin PL, Rodgers M, Fillmore D, Sakal J, Lin K, Vinette V, Schnappinger D, Ehrt S, Flynn JL. Smith AA, et al. Among authors: schnappinger d. bioRxiv [Preprint]. 2024 Sep 5:2023.11.22.568105. doi: 10.1101/2023.11.22.568105. bioRxiv. 2024. PMID: 38045242 Free PMC article. Preprint.
A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.
Choudhery S, DeJesus MA, Srinivasan A, Rock J, Schnappinger D, Ioerger TR. Choudhery S, et al. Among authors: schnappinger d. bioRxiv [Preprint]. 2024 Feb 7:2023.08.03.551759. doi: 10.1101/2023.08.03.551759. bioRxiv. 2024. Update in: PLoS Comput Biol. 2024 May 20;20(5):e1011408. doi: 10.1371/journal.pcbi.1011408 PMID: 37577548 Free PMC article. Updated. Preprint.
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.
Krieger IV, Yalamanchili S, Dickson P, Engelhart CA, Zimmerman MD, Wood J, Clary E, Nguyen J, Thornton N, Centrella PA, Chan B, Cuozzo JW, Gengenbacher M, Guié MA, Guilinger JP, Bienstock C, Hartl H, Hupp CD, Jetson R, Satoh T, Yeoman JTS, Zhang Y, Dartois V, Schnappinger D, Keefe AD, Sacchettini JC. Krieger IV, et al. Among authors: schnappinger d. ACS Infect Dis. 2024 May 10;10(5):1561-1575. doi: 10.1021/acsinfecdis.3c00592. Epub 2024 Apr 5. ACS Infect Dis. 2024. PMID: 38577994 Free PMC article.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M, Post JM, Lopez-Román EM, Engelhart CA, Lukac I, Zuccotto F, Epemolu O, Boshoff HIM, Schnappinger D, Walpole C, Gilbert IH, Read KD, Wyatt PG, Baragaña B. Green SR, et al. Among authors: schnappinger d. J Med Chem. 2023 Nov 23;66(22):15380-15408. doi: 10.1021/acs.jmedchem.3c01514. Epub 2023 Nov 10. J Med Chem. 2023. PMID: 37948640 Free PMC article.
134 results