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Therapeutic targeting of immunometabolism in Alzheimer's disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE. Codocedo JF, et al. Among authors: landreth ge. bioRxiv [Preprint]. 2023 Nov 15:2023.11.11.566270. doi: 10.1101/2023.11.11.566270. bioRxiv. 2023. Update in: Cell Rep. 2024 Jul 23;43(7):114488. doi: 10.1016/j.celrep.2024.114488. PMID: 38014106 Free PMC article. Updated. Preprint.
Bassoon contributes to tau-seed propagation and neurotoxicity.
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu YC, McKinzie DL, Rochet JC, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Martinez P, et al. Among authors: landreth ge. Nat Neurosci. 2022 Dec;25(12):1597-1607. doi: 10.1038/s41593-022-01191-6. Epub 2022 Nov 7. Nat Neurosci. 2022. PMID: 36344699 Free PMC article.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE. Tsai AP, et al. Among authors: landreth ge. Immunity. 2023 Sep 12;56(9):2121-2136.e6. doi: 10.1016/j.immuni.2023.08.008. Epub 2023 Sep 1. Immunity. 2023. PMID: 37659412 Free PMC article.
Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer's progression.
Codocedo JF, Mera-Reina C, Bor-Chian Lin P, Fallen PB, Puntambekar SS, Casali BT, Jury-Garfe N, Martinez P, Lasagna-Reeves CA, Landreth GE. Codocedo JF, et al. Among authors: landreth ge. Cell Rep. 2024 Jul 23;43(7):114488. doi: 10.1016/j.celrep.2024.114488. Epub 2024 Jul 13. Cell Rep. 2024. PMID: 39002124 Free PMC article.
169 results