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Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer.
Kiviaho A, Eerola SK, Kallio HML, Andersen MK, Hoikka M, Tiihonen AM, Salonen I, Spotbeen X, Giesen A, Parker CTA, Taavitsainen S, Hantula O, Marttinen M, Hermelo I, Ismail M, Midtbust E, Wess M, Devlies W, Sharma A, Krossa S, Häkkinen T, Afyounian E, Vandereyken K, Kint S, Kesseli J, Tolonen T, Tammela TLJ, Viset T, Størkersen Ø, Giskeødegård GF, Rye MB, Murtola T, Erickson A, Latonen L, Bova GS, Mills IG, Joniau S, Swinnen JV, Voet T, Mirtti T, Attard G, Claessens F, Visakorpi T, Rautajoki KJ, Tessem MB, Urbanucci A, Nykter M. Kiviaho A, et al. Among authors: hakkinen t. Nat Commun. 2024 Nov 16;15(1):9949. doi: 10.1038/s41467-024-54364-1. Nat Commun. 2024. PMID: 39550375 Free PMC article.
Patterning and folding of intestinal villi by active mesenchymal dewetting.
Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. Huycke TR, et al. Among authors: hakkinen tj. Cell. 2024 Jun 6;187(12):3072-3089.e20. doi: 10.1016/j.cell.2024.04.039. Epub 2024 May 22. Cell. 2024. PMID: 38781967 Free article.
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection.
Lin J, Moradi E, Salenius K, Lehtipuro S, Häkkinen T, Laiho JE, Oikarinen S, Randelin S, Parikh HM, Krischer JP, Toppari J, Lernmark Å, Petrosino JF, Ajami NJ, She JX, Hagopian WA, Rewers MJ, Lloyd RE, Rautajoki KJ, Hyöty H, Nykter M; TEDDY Study Group. Lin J, et al. Among authors: hakkinen t. Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. Nat Commun. 2023. PMID: 37993433 Free PMC article.
Patterning and folding of intestinal villi by active mesenchymal dewetting.
Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. Huycke TR, et al. Among authors: hakkinen tj. bioRxiv [Preprint]. 2023 Aug 15:2023.06.25.546328. doi: 10.1101/2023.06.25.546328. bioRxiv. 2023. Update in: Cell. 2024 Jun 6;187(12):3072-3089.e20. doi: 10.1016/j.cell.2024.04.039. PMID: 37425793 Free PMC article. Updated. Preprint.
The developmental basis for scaling of mammalian tooth size.
Christensen MM, Hallikas O, Das Roy R, Väänänen V, Stenberg OE, Häkkinen TJ, François JC, Asher RJ, Klein OD, Holzenberger M, Jernvall J. Christensen MM, et al. Among authors: hakkinen tj. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2300374120. doi: 10.1073/pnas.2300374120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307487 Free PMC article.
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge.
Bulten W, Kartasalo K, Chen PC, Ström P, Pinckaers H, Nagpal K, Cai Y, Steiner DF, van Boven H, Vink R, Hulsbergen-van de Kaa C, van der Laak J, Amin MB, Evans AJ, van der Kwast T, Allan R, Humphrey PA, Grönberg H, Samaratunga H, Delahunt B, Tsuzuki T, Häkkinen T, Egevad L, Demkin M, Dane S, Tan F, Valkonen M, Corrado GS, Peng L, Mermel CH, Ruusuvuori P, Litjens G, Eklund M; PANDA challenge consortium. Bulten W, et al. Among authors: hakkinen t. Nat Med. 2022 Jan;28(1):154-163. doi: 10.1038/s41591-021-01620-2. Epub 2022 Jan 13. Nat Med. 2022. PMID: 35027755 Free PMC article.
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse.
Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T, Granberg KJ, Lamb AD, Ketola K, Mills IG, Attard G, Wang W, Nykter M, Urbanucci A. Taavitsainen S, et al. Among authors: hakkinen t. Nat Commun. 2021 Sep 6;12(1):5307. doi: 10.1038/s41467-021-25624-1. Nat Commun. 2021. PMID: 34489465 Free PMC article.
38 results