Tang K - Search Results

1

Advances in drug structure-activity-relationships for the development of selenium-based compounds against HIV.

Shi D, Xu S, Ding D, Tang K, Zhou Y, Jiang X, Wang S, Liu X, Zhan P. Shi D, et al. Among authors: tang k. Expert Opin Drug Discov. 2024 Feb;19(2):139-146. doi: 10.1080/17460441.2023.2284830. Epub 2024 Feb 1. Expert Opin Drug Discov. 2024. PMID: 37988053 Review.

2

Hydrophobic tagging of small molecules: an overview of the literature and future outlook.

Zhou Y, Zhou F, Xu S, Shi D, Ding D, Wang S, Poongavanam V, Tang K, Liu X, Zhan P. Zhou Y, et al. Among authors: tang k. Expert Opin Drug Discov. 2024 Jul;19(7):799-813. doi: 10.1080/17460441.2024.2360416. Epub 2024 Jun 2. Expert Opin Drug Discov. 2024. PMID: 38825802 Review.

3

Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 M^pro Inhibitors With Robust Potency and Drug-like Profile.

Yang M, Lee MK, Gao S, Song L, Jang HY, Jo I, Yang CC, Sylvester K, Ko C, Wang S, Ye B, Tang K, Li J, Gu M, Müller CE, Sträter N, Liu X, Kim M, Zhan P. Yang M, et al. Among authors: tang k. Adv Sci (Weinh). 2024 Nov;11(43):e2404884. doi: 10.1002/advs.202404884. Epub 2024 Sep 25. Adv Sci (Weinh). 2024. PMID: 39319611 Free PMC article.

4

"Pseudosubstrate Envelope"/Free Energy Perturbation-Guided Design and Mechanistic Investigations of Benzothiazole HIV Capsid Modulators with High Ligand Efficiency.

Xu S, Wang S, Zhou Y, Foley N, Sun L, Walsham L, Tang K, Shi D, Shi X, Zhang Z, Jiang X, Gao S, Liu X, Pannecouque C, Goldstone DC, Dick A, Zhan P. Xu S, et al. Among authors: tang k. J Med Chem. 2024 Nov 14;67(21):19057-19076. doi: 10.1021/acs.jmedchem.4c01544. Epub 2024 Oct 17. J Med Chem. 2024. PMID: 39418501

5

Discovery of Novel Pyrazole-Based KDM5B Inhibitor TK-129 and Its Protective Effects on Myocardial Remodeling and Fibrosis.

Tang K, Jiao LM, Qi YR, Wang TC, Li YL, Xu JL, Wang ZW, Yu B, Liu HM, Zhao W. Tang K, et al. J Med Chem. 2022 Oct 13;65(19):12979-13000. doi: 10.1021/acs.jmedchem.2c00797. Epub 2022 Sep 16. J Med Chem. 2022. PMID: 36112701

6

Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.

Wang S, Zhao L, Shi XJ, Ding L, Yang L, Wang ZZ, Shen D, Tang K, Li XJ, Mamun M, Li H, Yu B, Zheng YC, Wang S, Liu HM. Wang S, et al. Among authors: tang k. J Med Chem. 2019 Mar 14;62(5):2772-2797. doi: 10.1021/acs.jmedchem.9b00113. Epub 2019 Mar 4. J Med Chem. 2019. PMID: 30803229

7

Harnessing the cyclization strategy for new drug discovery.

Tang K, Wang S, Gao W, Song Y, Yu B. Tang K, et al. Acta Pharm Sin B. 2022 Dec;12(12):4309-4326. doi: 10.1016/j.apsb.2022.09.022. Epub 2022 Oct 7. Acta Pharm Sin B. 2022. PMID: 36562004 Free PMC article. Review.

8

Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor.

Tang K, Wang S, Feng S, Yang X, Guo Y, Ren X, Bai L, Yu B, Liu HM, Song Y. Tang K, et al. Acta Pharm Sin B. 2024 Aug;14(8):3624-3642. doi: 10.1016/j.apsb.2024.03.028. Epub 2024 Mar 26. Acta Pharm Sin B. 2024. PMID: 39234614 Free PMC article.

9

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy.

Tang K, Wu YH, Song Y, Yu B. Tang K, et al. J Hematol Oncol. 2021 Apr 21;14(1):68. doi: 10.1186/s13045-021-01080-8. J Hematol Oncol. 2021. PMID: 33883013 Free PMC article. Review.

10

Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors.

Tang K, Zhao M, Wu YH, Wu Q, Wang S, Dong Y, Yu B, Song Y, Liu HM. Tang K, et al. Eur J Med Chem. 2022 Feb 15;230:114106. doi: 10.1016/j.ejmech.2022.114106. Epub 2022 Jan 12. Eur J Med Chem. 2022. PMID: 35063735

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