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Page 1
Glial reactivity is linked to synaptic dysfunction across the aging and Alzheimer's disease spectrum.
Pascoal T, Rohden F, Ferreira P, Bellaver B, Ferrari-Souza JP, Aguzzoli C, Soares C, Abbas S, Zalzale H, Povala G, Lussier F, Leffa D, Bauer-Negrini G, Rahmouni N, Tissot C, Therriault JT, Servaes S, Stevenson J, Benedet A, Ashton N, Karikari T, Tudorascu D, Zetterberg H, Blennow K, Zimmer E, Souza D, Rosa-Neto P. Pascoal T, et al. Among authors: povala g. Res Sq [Preprint]. 2024 Aug 12:rs.3.rs-4782732. doi: 10.21203/rs.3.rs-4782732/v1. Res Sq. 2024. PMID: 39184102 Free PMC article. Preprint.
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.
Zeng X, Lafferty TK, Sehrawat A, Chen Y, Ferreira PCL, Bellaver B, Povala G, Kamboh MI, Klunk WE, Cohen AD, Lopez OL, Ikonomovic MD, Pascoal TA, Ganguli M, Villemagne VL, Snitz BE, Karikari TK. Zeng X, et al. Among authors: povala g. medRxiv [Preprint]. 2024 Jun 16:2024.06.15.24308975. doi: 10.1101/2024.06.15.24308975. medRxiv. 2024. PMID: 38947065 Free PMC article. Preprint.
Vascular risk burden is a key player in the early progression of Alzheimer's disease.
Ferrari-Souza JP, Brum WS, Hauschild LA, Da Ros LU, Ferreira PCL, Bellaver B, Leffa DT, Bieger A, Tissot C, Lussier FZ, De Bastiani MA, Povala G, Benedet AL, Therriault J, Wang YT, Ashton NJ, Zetterberg H, Blennow K, Martins SO, Souza DO, Rosa-Neto P, Karikari TK, Pascoal TA, Zimmer ER; Alzheimer’s Disease Neuroimaging Initiative. Ferrari-Souza JP, et al. Among authors: povala g. Neurobiol Aging. 2024 Apr;136:88-98. doi: 10.1016/j.neurobiolaging.2023.12.008. Epub 2024 Jan 10. Neurobiol Aging. 2024. PMID: 38335912
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease.
Schaffer Aguzzoli C, Ferreira PCL, Povala G, Ferrari-Souza JP, Bellaver B, Soares Katz C, Zalzale H, Lussier FZ, Rohden F, Abbas S, Leffa DT, Scop Medeiros M, Therriault J, Benedet AL, Tissot C, Servaes S, Rahmouni N, Cassa Macedo A, Bezgin G, Kang MS, Stevenson J, Pallen V, Cohen A, Lopez OL, Tudorascu DL, Klunk WE, Villemagne VL, Soucy JP, Zimmer ER, Schilling LP, Karikari TK, Ashton NJ, Zetterberg H, Blennow K, Gauthier S, Valcour V, Miller BL, Rosa-Neto P, Pascoal TA. Schaffer Aguzzoli C, et al. Among authors: povala g. JAMA Netw Open. 2023 Nov 1;6(11):e2345175. doi: 10.1001/jamanetworkopen.2023.45175. JAMA Netw Open. 2023. PMID: 38010651 Free PMC article.
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease.
Gonzalez-Ortiz F, Ferreira PCL, González-Escalante A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H, Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Minguillon C, Contador J, Suárez-Calvet M, Karikari TK, Blennow K. Gonzalez-Ortiz F, et al. Among authors: povala g. Alzheimers Dement. 2024 Feb;20(2):1239-1249. doi: 10.1002/alz.13525. Epub 2023 Nov 17. Alzheimers Dement. 2024. PMID: 37975513 Free PMC article.
A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer's disease.
Gonzalez-Ortiz F, Ferreira PCL, Gonzalez A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H, Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Miguillon C, Contador J, Suarez-Calvet M, Karikari TK, Blennow K. Gonzalez-Ortiz F, et al. Among authors: povala g. medRxiv [Preprint]. 2023 Oct 5:2023.09.26.23296134. doi: 10.1101/2023.09.26.23296134. medRxiv. 2023. Update in: Alzheimers Dement. 2024 Feb;20(2):1239-1249. doi: 10.1002/alz.13525. PMID: 37873312 Free PMC article. Updated. Preprint.
APOEε4 potentiates amyloid β effects on longitudinal tau pathology.
Ferrari-Souza JP, Bellaver B, Ferreira PCL, Benedet AL, Povala G, Lussier FZ, Leffa DT, Therriault J, Tissot C, Soares C, Wang YT, Chamoun M, Servaes S, Macedo AC, Vermeiren M, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Cohen A, Lopez OL, Klunk WE, Soucy JP, Gauthier S, Souza DO, Triana-Baltzer G, Saad ZS, Kolb HC, Karikari TK, Villemagne VL, Tudorascu DL, Ashton NJ, Zetterberg H, Blennow K, Zimmer ER, Rosa-Neto P, Pascoal TA. Ferrari-Souza JP, et al. Among authors: povala g. Nat Aging. 2023 Oct;3(10):1210-1218. doi: 10.1038/s43587-023-00490-2. Epub 2023 Sep 25. Nat Aging. 2023. PMID: 37749258 Free PMC article.
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans.
Lima-Filho RAS, Benedet AL, De Bastiani MA, Povala G, Cozachenco D, Ferreira ST, De Felice FG, Rosa-Neto P, Zimmer ER, Lourenco MV; Alzheimer’s Disease Neuroimaging Initiative. Lima-Filho RAS, et al. Among authors: povala g. Brain Commun. 2023 Aug 17;5(4):fcad216. doi: 10.1093/braincomms/fcad216. eCollection 2023. Brain Commun. 2023. PMID: 37601408 Free PMC article.
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.
Ferreira PCL, Therriault J, Tissot C, Ferrari-Souza JP, Benedet AL, Povala G, Bellaver B, Leffa DT, Brum WS, Lussier FZ, Bezgin G, Servaes S, Vermeiren M, Macedo AC, Cabrera A, Stevenson J, Triana-Baltzer G, Kolb H, Rahmouni N, Klunk WE, Lopez OL, Villemagne VL, Cohen A, Tudorascu DL, Zimmer ER, Karikari TK, Ashton NJ, Zetterberg H, Blennow K, Gauthier S, Rosa-Neto P, Pascoal TA. Ferreira PCL, et al. Among authors: povala g. Alzheimers Dement. 2023 Oct;19(10):4463-4474. doi: 10.1002/alz.13393. Epub 2023 Aug 3. Alzheimers Dement. 2023. PMID: 37534889
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