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Pyrimidine Azepine Targets the Plasmodium bc 1 Complex and Displays Multistage Antimalarial Activity.
Calit J, Prajapati SK, Benavente ED, Araújo JE, Deng B, Miura K, Annunciato Y, Moura IMR, Usui M, Medeiros JF, Andrade CH, Silva-Mendonça S, Simeonov A, Eastman RT, Long CA, da Silva Araujo M, Williamson KC, Aguiar ACC, Bargieri DY. Calit J, et al. Among authors: eastman rt. JACS Au. 2024 Oct 7;4(10):3942-3952. doi: 10.1021/jacsau.4c00674. eCollection 2024 Oct 28. JACS Au. 2024. PMID: 39483245 Free PMC article.
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.
Barkan DT, Garland K, Zhang L, Eastman RT, Hesse M, Knapp M, Ornelas E, Tang J, Cortopassi WA, Wang Y, King F, Jia W, Nguyen Z, Frank AO, Chan R, Fang E, Fuller D, Busby S, Carias H, Donahue K, Tandeske L, Diagana TT, Jarrousse N, Moser H, Sarko C, Dovala D, Moquin S, Marx VM. Barkan DT, et al. Among authors: eastman rt. J Med Chem. 2024 Oct 10;67(19):17454-17471. doi: 10.1021/acs.jmedchem.4c01404. Epub 2024 Sep 27. J Med Chem. 2024. PMID: 39332817 Free PMC article.
Establishment of human post-vaccination SARS-CoV-2 standard reference sera.
Xiang J, Katz L, Winokur PL, Chaudhary A, Digmann B, Bradford R, Rashid S, Ghosh S, Robertson A, Menetski J, Xu M, Gao P, Chen CZ, Lee T, Poelaert B, Eastman RT, Hall MD, Stapleton JT. Xiang J, et al. Among authors: eastman rt. J Immunol Methods. 2024 Jul;530:113698. doi: 10.1016/j.jim.2024.113698. Epub 2024 May 31. J Immunol Methods. 2024. PMID: 38823574 Free article.
Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
Yasgar A, Bougie D, Eastman RT, Huang R, Itkin M, Kouznetsova J, Lynch C, McKnight C, Miller M, Ngan DK, Peryea T, Shah P, Shinn P, Xia M, Xu X, Zakharov AV, Simeonov A. Yasgar A, et al. Among authors: eastman rt. ACS Pharmacol Transl Sci. 2023 Apr 14;6(5):683-701. doi: 10.1021/acsptsci.2c00194. eCollection 2023 May 12. ACS Pharmacol Transl Sci. 2023. PMID: 37200814 Free PMC article.
A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.
Fu Y, da Fonseca Rezende E Mello J, Fleming BD, Renn A, Chen CZ, Hu X, Xu M, Gorshkov K, Hanson Q, Zheng W, Lee EM, Perera L, Petrovich R, Pradhan M, Eastman RT, Itkin Z, Stanley TB, Hsu A, Dandey V, Sharma K, Gillette W, Taylor T, Ramakrishnan N, Perkins S, Esposito D, Oh E, Susumu K, Wolak M, Ferrer M, Hall MD, Borgnia MJ, Simeonov A. Fu Y, et al. Among authors: eastman rt. PLoS One. 2022 Aug 10;17(8):e0272364. doi: 10.1371/journal.pone.0272364. eCollection 2022. PLoS One. 2022. PMID: 35947606 Free PMC article.
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