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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, Reiman EM, Mahley RW, Huang Y. Nelson MR, et al. Among authors: mahley rw. Nat Neurosci. 2023 Dec;26(12):2104-2121. doi: 10.1038/s41593-023-01480-8. Epub 2023 Nov 13. Nat Neurosci. 2023. PMID: 37957317 Free PMC article.
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Marino C, Perez-Corredor P, O'Hare M, Heuer A, Chmielewska N, Gordon H, Chandrahas AS, Gonzalez-Buendia L, Delgado-Tirado S, Doan TH, Vanderleest TE, Arevalo-Alquichire S, Obar RA, Ortiz-Cordero C, Villegas A, Sepulveda-Falla D, Kim LA, Lopera F, Mahley R, Huang Y, Quiroz YT, Arboleda-Velasquez JF. Marino C, et al. Alzheimers Dement. 2024 Feb;20(2):819-836. doi: 10.1002/alz.13436. Epub 2023 Oct 4. Alzheimers Dement. 2024. PMID: 37791598 Free PMC article.
Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.
Cakir Z, Lord SJ, Zhou Y, Jang GM, Polacco BJ, Eckhardt M, Jimenez-Morales D, Newton BW, Orr AL, Johnson JR, da Cruz A, Mullins RD, Krogan NJ, Mahley RW, Swaney DL. Cakir Z, et al. Among authors: mahley rw. Mol Cell Proteomics. 2023 May;22(5):100541. doi: 10.1016/j.mcpro.2023.100541. Epub 2023 Apr 4. Mol Cell Proteomics. 2023. PMID: 37019383 Free PMC article.
The enhancer RNA, AANCR, regulates APOE expression in astrocytes and microglia.
Wan M, Liu Y, Li D, Snyder RJ, Elkin LB, Day CR, Rodriguez J, Grunseich C, Mahley RW, Watts JA, Cheung VG. Wan M, et al. Among authors: mahley rw. Nucleic Acids Res. 2024 Sep 23;52(17):10235-10254. doi: 10.1093/nar/gkae696. Nucleic Acids Res. 2024. PMID: 39162226 Free PMC article.
303 results