Simon IA - Search Results

1

Ligand selectivity hotspots in serotonin GPCRs.

Simon IA, Bjørn-Yoshimoto WE, Harpsøe K, Iliadis S, Svensson B, Jensen AA, Gloriam DE. Simon IA, et al. Trends Pharmacol Sci. 2023 Dec;44(12):978-990. doi: 10.1016/j.tips.2023.09.012. Epub 2023 Oct 31. Trends Pharmacol Sci. 2023. PMID: 37914598 Free article. Review.

2

Structural insights into the lipid and ligand regulation of serotonin receptors.

Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsøe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE. Xu P, et al. Among authors: simon ia. Nature. 2021 Apr;592(7854):469-473. doi: 10.1038/s41586-021-03376-8. Epub 2021 Mar 24. Nature. 2021. PMID: 33762731

3

GPCRs steer G_i and G_s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsøe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE. Huang S, et al. Among authors: simon ia. Mol Cell. 2022 Jul 21;82(14):2681-2695.e6. doi: 10.1016/j.molcel.2022.05.031. Epub 2022 Jun 16. Mol Cell. 2022. PMID: 35714614 Free article.

4

Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT_2A Receptor Agonists.

Pottie E, Poulie CBM, Simon IA, Harpsøe K, D'Andrea L, Komarov IV, Gloriam DE, Jensen AA, Kristensen JL, Stove CP. Pottie E, et al. Among authors: simon ia. ACS Chem Neurosci. 2023 Aug 2;14(15):2727-2742. doi: 10.1021/acschemneuro.3c00267. Epub 2023 Jul 20. ACS Chem Neurosci. 2023. PMID: 37474114 Free PMC article.

5

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT_2A Receptor Agonists.

Poulie CBM, Pottie E, Simon IA, Harpsøe K, D'Andrea L, Komarov IV, Gloriam DE, Jensen AA, Stove CP, Kristensen JL. Poulie CBM, et al. Among authors: simon ia. J Med Chem. 2022 Sep 22;65(18):12031-12043. doi: 10.1021/acs.jmedchem.2c00702. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36099411 Free PMC article.

6

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3.

Zarca AM, Adlere I, Viciano CP, Arimont-Segura M, Meyrath M, Simon IA, Bebelman JP, Laan D, Custers HGJ, Janssen E, Versteegh KL, Buzink MCML, Nesheva DN, Bosma R, de Esch IJP, Vischer HF, Wijtmans M, Szpakowska M, Chevigné A, Hoffmann C, de Graaf C, Zarzycka BA, Windhorst AD, Smit MJ, Leurs R. Zarca AM, et al. Among authors: simon ia. Mol Pharmacol. 2024 Mar 14;105(4):301-312. doi: 10.1124/molpharm.123.000835. Mol Pharmacol. 2024. PMID: 38346795

7

PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands.

Simon IA, Homan EJ, Wijtmans M, Sundström M, Leurs R, De Esch IJP, Zarzycka BA. Simon IA, et al. J Chem Inf Model. 2023 Nov 13;63(21):6696-6705. doi: 10.1021/acs.jcim.3c01050. Epub 2023 Oct 13. J Chem Inf Model. 2023. PMID: 37831965 Free PMC article.

8

A switch in N-terminal capping of β-peptides creates novel self-assembled nanoparticles.

Chen YK, Simon IA, Maslov I, Oyarce-Pino IE, Kulkarni K, Hopper D, Aguilar MI, Vankadari N, Broughton BR, Del Borgo MP. Chen YK, et al. Among authors: simon ia. RSC Adv. 2023 Oct 9;13(42):29401-29407. doi: 10.1039/d3ra04514e. eCollection 2023 Oct 4. RSC Adv. 2023. PMID: 37818265 Free PMC article.

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