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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. Tayeb-Fligelman E, et al. Among authors: garcia g jr. Nat Commun. 2023 Apr 25;14(1):2379. doi: 10.1038/s41467-023-37865-3. Nat Commun. 2023. PMID: 37185252 Free PMC article.
Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses.
Garcia G Jr, Irudayam JI, Jeyachandran AV, Dubey S, Chang C, Castillo Cario S, Price N, Arumugam S, Marquez AL, Shah A, Fanaei A, Chakravarty N, Joshi S, Sinha S, French SW, Parcells MS, Ramaiah A, Arumugaswami V. Garcia G Jr, et al. Cell Rep Med. 2023 May 16;4(5):101024. doi: 10.1016/j.xcrm.2023.101024. Epub 2023 Apr 28. Cell Rep Med. 2023. PMID: 37119814 Free PMC article.
Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses.
Garcia G Jr, Irudayam JI, Jeyachandran AV, Dubey S, Chang C, Cario SC, Price N, Arumugam S, Marquez AL, Shah A, Fanaei A, Chakravarty N, Joshi S, Sinha S, French SW, Parcells M, Ramaiah A, Arumugaswami V. Garcia G Jr, et al. bioRxiv [Preprint]. 2023 Jan 20:2023.01.19.524824. doi: 10.1101/2023.01.19.524824. bioRxiv. 2023. Update in: Cell Rep Med. 2023 May 16;4(5):101024. doi: 10.1016/j.xcrm.2023.101024. PMID: 36711787 Free PMC article. Updated. Preprint.
Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection.
Contreras D, Garcia G Jr, Jones MK, Martinez LE, Jayakarunakaran A, Gangalapudi V, Tang J, Wu Y, Zhao JJ, Chen Z, Ramaiah A, Tsui I, Kumar A, Nielsen-Saines K, Wang S, Arumugaswami V. Contreras D, et al. Among authors: garcia g jr. Viruses. 2023 Jan 1;15(1):142. doi: 10.3390/v15010142. Viruses. 2023. PMID: 36680182 Free PMC article.
Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response.
Garcia G Jr, Wang Y, Ignatius Irudayam J, Jeyachandran AV, Cario SC, Sen C, Li S, Li Y, Kumar A, Nielsen-Saines K, French SW, Shah PS, Morizono K, Gomperts B, Deb A, Ramaiah A, Arumugaswami V. Garcia G Jr, et al. bioRxiv [Preprint]. 2022 Apr 8:2022.04.07.487520. doi: 10.1101/2022.04.07.487520. bioRxiv. 2022. Update in: PLoS Biol. 2022 Nov 8;20(11):e3001851. doi: 10.1371/journal.pbio.3001851. PMID: 35441167 Free PMC article. Updated. Preprint.
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