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Page 1
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: sainz ag. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Wu Z, et al. Among authors: sainz ag. Nat Metab. 2019 Dec;1(12):1209-1218. doi: 10.1038/s42255-019-0150-8. Epub 2019 Dec 9. Nat Metab. 2019. PMID: 32395698 Free PMC article.
Mitochondrial DNA: cellular genotoxic stress sentinel.
Wu Z, Sainz AG, Shadel GS. Wu Z, et al. Among authors: sainz ag. Trends Biochem Sci. 2021 Oct;46(10):812-821. doi: 10.1016/j.tibs.2021.05.004. Epub 2021 Jun 1. Trends Biochem Sci. 2021. PMID: 34088564 Free PMC article. Review.
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: sainz ag. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Among authors: sainz ag. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions.
Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. Hepokoski ML, et al. Among authors: sainz ag. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L84-L92. doi: 10.1152/ajplung.00128.2022. Epub 2022 Jun 14. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35699291 Free PMC article.
Diet as a moderator in the association of sedentary behaviors with inflammatory biomarkers among adolescents in the HELENA study.
Arouca AB, Santaliestra-Pasías AM, Moreno LA, Marcos A, Widhalm K, Molnár D, Manios Y, Gottrand F, Kafatos A, Kersting M, Sjöström M, Sáinz ÁG, Ferrari M, Huybrechts I, González-Gross M, Forsner M, De Henauw S, Michels N; HELENA study group. Arouca AB, et al. Among authors: sainz ag. Eur J Nutr. 2019 Aug;58(5):2051-2065. doi: 10.1007/s00394-018-1764-4. Epub 2018 Jul 4. Eur J Nutr. 2019. PMID: 29974229
22 results