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Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD. Caruso JA, et al. Among authors: tlsty td. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2303774120. doi: 10.1073/pnas.2303774120. Epub 2023 Oct 10. Proc Natl Acad Sci U S A. 2023. PMID: 37816052 Free PMC article.
Remaining true to one's identity.
Caruso JA, Tlsty TD. Caruso JA, et al. Among authors: tlsty td. Nat Aging. 2021 Sep;1(9):757-759. doi: 10.1038/s43587-021-00113-8. Nat Aging. 2021. PMID: 37117630 Free PMC article.
Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition.
Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, Roland JT, Hong SH, Sohn Y, Krystofiak E, Jang B, Ferri L, Sangwan V, Ragoussis J, Camilleri-Broët S, Caruso J, Chen-Tanyolac C, Strasser M, Gascard P, Tlsty TD, Huang S, Choi E, Goldenring JR. Lee SH, et al. Among authors: tlsty td. Gastroenterology. 2023 Aug;165(2):374-390. doi: 10.1053/j.gastro.2023.04.038. Epub 2023 May 15. Gastroenterology. 2023. PMID: 37196797 Free PMC article.
Epithelial-Stromal Interactions in Barrett's Esophagus Modeled in Human Organ Chips.
Shimshoni E, Merry GE, Milot ZD, Oh CY, Horvath V, Gould RA, Caruso JA, Chen-Tanyolac C, Gascard P, Sangwan V, Bérubé J, Bailey SD, Hall S, Stachler MD, Ferri L, Tlsty TD, Ingber DE. Shimshoni E, et al. Among authors: tlsty td. Gastro Hep Adv. 2023 Mar 9;2(5):676-680. doi: 10.1016/j.gastha.2023.03.009. eCollection 2023. Gastro Hep Adv. 2023. PMID: 39129866 Free PMC article. Review. No abstract available.
Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis.
Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Camilleri-Broet S, Fiset PO, Bertos N, Berube J, Djambazian H, Li R, Oikonomopoulos S, Fels-Elliott DR, Vernovsky S, Shimshoni E, Collyar D, Russell A, Ragoussis I, Stachler M, Goldenring JR, McDonald S, Ingber DE, Schilling B, Nolan GP, Tlsty TD, Huang S, Ferri LE. Strasser MK, et al. Among authors: tlsty td. bioRxiv [Preprint]. 2023 Jun 11:2023.06.08.544265. doi: 10.1101/2023.06.08.544265. bioRxiv. 2023. PMID: 37333362 Free PMC article. Preprint.
Defining precancer: a grand challenge for the cancer community.
Faupel-Badger J, Kohaar I, Bahl M, Chan AT, Campbell JD, Ding L, De Marzo AM, Maitra A, Merrick DT, Hawk ET, Wistuba II, Ghobrial IM, Lippman SM, Lu KH, Lawler M, Kay NE, Tlsty TD, Rebbeck TR, Srivastava S; Precancer Think Tank Team. Faupel-Badger J, et al. Among authors: tlsty td. Nat Rev Cancer. 2024 Nov;24(11):792-809. doi: 10.1038/s41568-024-00744-0. Epub 2024 Oct 1. Nat Rev Cancer. 2024. PMID: 39354069 Review.
Data-independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation-associated carcinomas.
Bons J, Pan D, Shah S, Bai R, Chen-Tanyolac C, Wang X, Elliott DRF, Urisman A, O'Broin A, Basisty N, Rose J, Sangwan V, Camilleri-Broët S, Tankel J, Gascard P, Ferri L, Tlsty TD, Schilling B. Bons J, et al. Among authors: tlsty td. Proteomics. 2023 Apr;23(7-8):e2200021. doi: 10.1002/pmic.202200021. Epub 2022 Oct 13. Proteomics. 2023. PMID: 36228107 Free PMC article.
115 results