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Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.
Jo T, Kim J, Bice P, Huynh K, Wang T, Arnold M, Meikle PJ, Giles C, Kaddurah-Daouk R, Saykin AJ, Nho K; Alzheimer's Disease Metabolomics Consortium (ADMC); Alzheimer's Disease Neuroimaging Initiative (ADNI). Jo T, et al. Among authors: meikle pj. EBioMedicine. 2023 Nov;97:104820. doi: 10.1016/j.ebiom.2023.104820. Epub 2023 Oct 7. EBioMedicine. 2023. PMID: 37806288 Free PMC article.
A blood-based signature of cerebrospinal fluid Aβ1-42 status.
Goudey B, Fung BJ, Schieber C, Faux NG; Alzheimer’s Disease Metabolomics Consortium; Alzheimer’s Disease Neuroimaging Initiative. Goudey B, et al. Sci Rep. 2019 Mar 11;9(1):4163. doi: 10.1038/s41598-018-37149-7. Sci Rep. 2019. PMID: 30853713 Free PMC article.
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.
Baloni P, Funk CC, Yan J, Yurkovich JT, Kueider-Paisley A, Nho K, Heinken A, Jia W, Mahmoudiandehkordi S, Louie G, Saykin AJ, Arnold M, Kastenmüller G, Griffiths WJ, Thiele I; Alzheimer’s Disease Metabolomics Consortium; Kaddurah-Daouk R, Price ND. Baloni P, et al. Cell Rep Med. 2020 Nov 17;1(8):100138. doi: 10.1016/j.xcrm.2020.100138. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294859 Free PMC article.
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Among authors: meikle pj. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer's disease.
Kim JP, Nho K, Wang T, Huynh K, Arnold M, Risacher SL, Bice PJ, Han X, Kristal BS, Blach C, Baillie R, Kastenmüller G, Meikle PJ, Saykin AJ, Kaddurah-Daouk R; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Metabolomics Consortium. Kim JP, et al. Among authors: meikle pj. medRxiv [Preprint]. 2023 Jun 21:2023.06.12.23291054. doi: 10.1101/2023.06.12.23291054. medRxiv. 2023. PMID: 37398438 Free PMC article. Preprint.
A Modified Mediterranean Ketogenic Diet mitigates modifiable risk factors of Alzheimer's Disease: a serum and CSF-based metabolic analysis.
Schweickart A, Batra R, Neth BJ, Martino C, Shenhav L, Zhang AR, Shi P, Karu N, Huynh K, Meikle PJ, Schimmel L, Dilmore AH, Blennow K, Zetterberg H, Blach C, Dorrestein PC, Knight R; Alzheimer’s Gut Microbiome Project Consortium; Craft S, Kaddurah-Daouk R, Krumsiek J. Schweickart A, et al. Among authors: meikle pj. medRxiv [Preprint]. 2023 Nov 27:2023.11.27.23298990. doi: 10.1101/2023.11.27.23298990. medRxiv. 2023. Update in: NPJ Metab Health Dis. 2024;2(1):15. doi: 10.1038/s44324-024-00016-3. PMID: 38076824 Free PMC article. Updated. Preprint.
Development and validation of a plasmalogen score as an independent modifiable marker of metabolic health: population based observational studies and a placebo-controlled cross-over study.
Beyene HB, Huynh K, Wang T, Paul S, Cinel M, Mellett NA, Olshansky G, Meikle TG, Watts GF, Hung J, Hui J, Beilby J, Blangero J, Moses EK, Shaw JE, Magliano DJ, Giles C, Meikle PJ. Beyene HB, et al. Among authors: meikle pj. EBioMedicine. 2024 Jul;105:105187. doi: 10.1016/j.ebiom.2024.105187. Epub 2024 Jun 10. EBioMedicine. 2024. PMID: 38861870 Free PMC article.
A lipidomic based metabolic age score captures cardiometabolic risk independent of chronological age.
Wang T, Beyene HB, Yi C, Cinel M, Mellett NA, Olshansky G, Meikle TG, Wu J, Dakic A, Watts GF, Hung J, Hui J, Beilby J, Blangero J, Kaddurah-Daouk R, Salim A, Moses EK, Shaw JE, Magliano DJ, Huynh K, Giles C, Meikle PJ. Wang T, et al. Among authors: meikle pj. EBioMedicine. 2024 Jul;105:105199. doi: 10.1016/j.ebiom.2024.105199. Epub 2024 Jun 20. EBioMedicine. 2024. PMID: 38905750 Free PMC article.
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease.
Schweickart A, Batra R, Neth BJ, Martino C, Shenhav L, Zhang AR, Shi P, Karu N, Huynh K, Meikle PJ, Schimmel L, Dilmore AH, Blennow K, Zetterberg H, Blach C, Dorrestein PC, Knight R; Alzheimer’s Gut Microbiome Project Consortium; Craft S, Kaddurah-Daouk R, Krumsiek J. Schweickart A, et al. Among authors: meikle pj. NPJ Metab Health Dis. 2024;2(1):15. doi: 10.1038/s44324-024-00016-3. Epub 2024 Jul 1. NPJ Metab Health Dis. 2024. PMID: 38962750 Free PMC article.
Lipidomic Risk Score to Enhance Cardiovascular Risk Stratification for Primary Prevention.
Wu J, Giles C, Dakic A, Beyene HB, Huynh K, Wang T, Meikle T, Olshansky G, Salim A, Duong T, Watts GF, Hung J, Hui J, Cadby G, Beilby J, Blangero J, Moses EK, Shaw JE, Magliano DJ, Zhu D, Yang JY, Grieve SM, Wilson A, Chow CK, Vernon ST, Gray MP, Figtree GA, Carrington MJ, Inouye M, Marwick TH, Meikle PJ. Wu J, et al. Among authors: meikle pj. J Am Coll Cardiol. 2024 Jul 30;84(5):434-446. doi: 10.1016/j.jacc.2024.04.060. J Am Coll Cardiol. 2024. PMID: 39048275 Free article.
319 results