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Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Drigo RAE. Dos Santos C, et al. Among authors: shrestha s. Res Sq [Preprint]. 2023 Sep 20:rs.3.rs-3311459. doi: 10.21203/rs.3.rs-3311459/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2. PMID: 37790446 Free PMC article. Updated. Preprint.
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, E Drigo RA. Dos Santos C, et al. Among authors: shrestha s. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554369. doi: 10.1101/2023.08.23.554369. bioRxiv. 2023. PMID: 37662336 Free PMC article. Preprint.
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice.
Dos Santos C, Cambraia A, Shrestha S, Cutler M, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Arrojo E Drigo R. Dos Santos C, et al. Among authors: shrestha s. Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2. Nat Commun. 2024. PMID: 39433757 Free PMC article.
Genetic risk converges on regulatory networks mediating early type 2 diabetes.
Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE; HPAP Consortium; Parker SCJ, Powers AC, Brissova M. Walker JT, et al. Among authors: shrestha s. Nature. 2023 Dec;624(7992):621-629. doi: 10.1038/s41586-023-06693-2. Epub 2023 Dec 4. Nature. 2023. PMID: 38049589 Free PMC article.
Knockdown of microglial iron import gene, DMT1, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease.
Robertson KV, Rodriguez AS, Cartailler JP, Shrestha S, Schroeder KR, Valenti AM, Harrison FE, Hasty AH. Robertson KV, et al. Among authors: shrestha s. Res Sq [Preprint]. 2024 Jun 27:rs.3.rs-4559940. doi: 10.21203/rs.3.rs-4559940/v1. Res Sq. 2024. Update in: J Neuroinflammation. 2024 Sep 27;21(1):238. doi: 10.1186/s12974-024-03238-w. PMID: 38978579 Free PMC article. Updated. Preprint.
The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.
Nakhe AY, Dadi PK, Kim J, Dickerson MT, Behera S, Dobson JR, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA. Nakhe AY, et al. Among authors: shrestha s. bioRxiv [Preprint]. 2024 Feb 27:2023.06.20.545631. doi: 10.1101/2023.06.20.545631. bioRxiv. 2024. Update in: Elife. 2024 May 03;12:RP89967. doi: 10.7554/eLife.89967. PMID: 37546831 Free PMC article. Updated. Preprint.
3,349 results