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ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis.
Guillet S, Lazarov T, Jordan N, Boisson B, Tello M, Craddock B, Zhou T, Nishi C, Bareja R, Yang H, Rieux-Laucat F, Fregel Lorenzo RI, Dyall SD, Isenberg D, D'Cruz D, Lachmann N, Elemento O, Viale A, Socci ND, Abel L, Nagata S, Huse M, Miller WT, Casanova JL, Geissmann F. Guillet S, et al. Among authors: viale a. Elife. 2024 Nov 21;13:RP96085. doi: 10.7554/eLife.96085. Elife. 2024. PMID: 39570652 Free PMC article.
WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer.
Citron F, Ho IL, Balestrieri C, Liu Z, Yen EY, Cecchetto L, Perelli L, Zhang L, Montanez LC, Blazanin N, Dyke CA, Shah R, Attanasio S, Srinivasan S, Chen KC, Chen Z, Scognamiglio I, Pham N, Khan H, Jiang S, Pan J, Vanderkruk B, Leung CS, Mattohti M, Rai K, Chu Y, Wang L, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Xiong Y, Lorenzi PL, Bonini C, Anna Zal M, Hoffman BG, Heffernan T, Giuliani V, Jeter CR, Lissanu Y, Genovese G, Pilato MD, Viale A, Draetta GF. Citron F, et al. Among authors: viale a. bioRxiv [Preprint]. 2024 Oct 24:2024.10.21.619543. doi: 10.1101/2024.10.21.619543. bioRxiv. 2024. PMID: 39484624 Free PMC article. Preprint.
Mechanism of neurodegeneration mediated by clonal inflammatory microglia.
Vicario R, Fragkogianni S, Pokrovskii M, Mayer C, Lopez-Rodrigo E, Hu Y, Ogishi M, Alberdi A, Baako A, Ay O, Plu I, Sazdovitch V, Heritier S, Cohen-Aubart F, Shor N, Miyara M, Nguyen-Khac F, Viale A, Idbaih A, Amoura Z, Rosenblum MK, Zhang H, Karnoub ER, Sashittal P, Jakatdar A, Iacobuzio-Donahue CA, Abdel-Wahab O, Tabar V, Socci ND, Elemento O, Diamond EL, Boisson B, Casanova JL, Seilhean D, Haroche J, Donadieu J, Geissmann F. Vicario R, et al. Among authors: viale a. bioRxiv [Preprint]. 2024 Jul 31:2024.07.30.605867. doi: 10.1101/2024.07.30.605867. bioRxiv. 2024. PMID: 39131366 Free PMC article. Preprint.
Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer.
McPherson A, Vázquez-García I, Myers MA, Zatzman M, Al-Rawi D, Weiner A, Freeman S, Mohibullah N, Satas G, Williams MJ, Ceglia N, Zhang AW, Li J, Lim JLP, Wu M, Choi S, Havasov E, Grewal D, Shi H, Kim M, Schwarz R, Kaufmann T, Dinh KN, Uhlitz F, Tran J, Wu Y, Patel R, Ramakrishnan S, Kim D, Clarke J, Green H, Ali E, DiBona M, Varice N, Kundra R, Broach V, Gardner GJ, Roche KL, Sonoda Y, Zivanovic O, Kim SH, Grisham RN, Liu YL, Viale A, Rusk N, Lakhman Y, Ellenson LH, Tavaré S, Aparicio S, Chi DS, Aghajanian C, Abu-Rustum NR, Friedman CF, Zamarin D, Weigelt B, Bakhoum SF, Shah SP. McPherson A, et al. Among authors: viale a. bioRxiv [Preprint]. 2024 Jul 15:2024.07.11.602772. doi: 10.1101/2024.07.11.602772. bioRxiv. 2024. PMID: 39071261 Free PMC article. Preprint.
Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer.
Lenis AT, Ravichandran V, Brown S, Alam SM, Katims A, Truong H, Reisz PA, Vasselman S, Nweji B, Autio KA, Morris MJ, Slovin SF, Rathkopf D, Danila D, Woo S, Vargas HA, Laudone VP, Ehdaie B, Reuter V, Arcila M, Berger MF, Viale A, Scher HI, Schultz N, Gopalan A, Donoghue MTA, Ostrovnaya I, Stopsack KH, Solit DB, Abida W. Lenis AT, et al. Among authors: viale a. Clin Cancer Res. 2024 Sep 3;30(17):3894-3903. doi: 10.1158/1078-0432.CCR-23-3403. Clin Cancer Res. 2024. PMID: 38949888
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis.
Guillet S, Lazarov T, Jordan N, Boisson B, Tello M, Craddock B, Zhou T, Nishi C, Bareja R, Yang H, Rieux-Laucat F, Lorenzo RIF, Dyall SD, Isenberg D, D'Cruz D, Lachmann N, Elemento O, Viale A, Socci ND, Abel L, Nagata S, Huse M, Miller WT, Casanova JL, Geissmann F. Guillet S, et al. Among authors: viale a. medRxiv [Preprint]. 2024 Jun 5:2024.02.15.24302255. doi: 10.1101/2024.02.15.24302255. medRxiv. 2024. Update in: Elife. 2024 Nov 21;13:RP96085. doi: 10.7554/eLife.96085. PMID: 38883731 Free PMC article. Updated. Preprint.
Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer.
Cortesi A, Gandolfi F, Arco F, Di Chiaro P, Valli E, Polletti S, Noberini R, Gualdrini F, Attanasio S, Citron F, Ho IL, Shah R, Yen EY, Spinella MC, Ronzoni S, Rodighiero S, Mitro N, Bonaldi T, Ghisletti S, Monticelli S, Viale A, Diaferia GR, Natoli G. Cortesi A, et al. Among authors: viale a. Sci Adv. 2024 Mar 29;10(13):eadk5386. doi: 10.1126/sciadv.adk5386. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536927 Free PMC article.
Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho IL, Li CY, Wang F, Zhao L, Liu J, Yen EY, Dyke CA, Shah R, Liu Z, Çetin AO, Chu Y, Citron F, Attanasio S, Corti D, Darbaniyan F, Del Poggetto E, Loponte S, Liu J, Soeung M, Chen Z, Jiang S, Jiang H, Inoue A, Gao S, Deem A, Feng N, Ying H, Kim M, Giuliani V, Genovese G, Zhang J, Futreal A, Maitra A, Heffernan T, Wang L, Do KA, Gargiulo G, Draetta G, Carugo A, Lin R, Viale A. Ho IL, et al. Among authors: viale a. Sci Adv. 2024 Mar 15;10(11):eadd9342. doi: 10.1126/sciadv.add9342. Epub 2024 Mar 13. Sci Adv. 2024. PMID: 38478609 Free article.
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.
Thongon N, Ma F, Baran N, Lockyer P, Liu J, Jackson C, Rose A, Furudate K, Wildeman B, Marchesini M, Marchica V, Storti P, Todaro G, Ganan-Gomez I, Adema V, Rodriguez-Sevilla JJ, Qing Y, Ha MJ, Fonseca R, Stein C, Class C, Tan L, Attanasio S, Garcia-Manero G, Giuliani N, Berrios Nolasco D, Santoni A, Cerchione C, Bueso-Ramos C, Konopleva M, Lorenzi P, Takahashi K, Manasanch E, Sammarelli G, Kanagal-Shamanna R, Viale A, Chesi M, Colla S. Thongon N, et al. Among authors: viale a. Nat Commun. 2024 Feb 8;15(1):1203. doi: 10.1038/s41467-024-45350-8. Nat Commun. 2024. PMID: 38331987 Free PMC article.
A microglia clonal inflammatory disorder in Alzheimer's Disease.
Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock BP, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R; Netherlands Brain Bank; Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. Vicario R, et al. Among authors: viale a. bioRxiv [Preprint]. 2024 Aug 3:2024.01.25.577216. doi: 10.1101/2024.01.25.577216. bioRxiv. 2024. PMID: 38328106 Free PMC article. Preprint.
384 results