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PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FHA, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland J. Wartewig T, et al. Among authors: klement c. Nat Cancer. 2023 Oct;4(10):1508-1525. doi: 10.1038/s43018-023-00635-7. Epub 2023 Sep 18. Nat Cancer. 2023. PMID: 37723306 Free PMC article.
HDAC2 Facilitates Pancreatic Cancer Metastasis.
Krauß L, Urban BC, Hastreiter S, Schneider C, Wenzel P, Hassan Z, Wirth M, Lankes K, Terrasi A, Klement C, Cernilogar FM, Öllinger R, de Andrade Krätzig N, Engleitner T, Schmid RM, Steiger K, Rad R, Krämer OH, Reichert M, Schotta G, Saur D, Schneider G. Krauß L, et al. Among authors: klement c. Cancer Res. 2022 Feb 15;82(4):695-707. doi: 10.1158/0008-5472.CAN-20-3209. Cancer Res. 2022. PMID: 34903606 Free PMC article.
Non-canonical functions of SNAIL drive context-specific cancer progression.
Paul MC, Schneeweis C, Falcomatà C, Shan C, Rossmeisl D, Koutsouli S, Klement C, Zukowska M, Widholz SA, Jesinghaus M, Heuermann KK, Engleitner T, Seidler B, Sleiman K, Steiger K, Tschurtschenthaler M, Walter B, Weidemann SA, Pietsch R, Schnieke A, Schmid RM, Robles MS, Andrieux G, Boerries M, Rad R, Schneider G, Saur D. Paul MC, et al. Among authors: klement c. Nat Commun. 2023 Mar 7;14(1):1201. doi: 10.1038/s41467-023-36505-0. Nat Commun. 2023. PMID: 36882420 Free PMC article.
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Fischer A, Lersch R, de Andrade Krätzig N, Strong A, Friedrich MJ, Weber J, Engleitner T, Öllinger R, Yen HY, Kohlhofer U, Gonzalez-Menendez I, Sailer D, Kogan L, Lahnalampi M, Laukkanen S, Kaltenbacher T, Klement C, Rezaei M, Ammon T, Montero JJ, Schneider G, Mayerle J, Heikenwälder M, Schmidt-Supprian M, Quintanilla-Martinez L, Steiger K, Liu P, Cadiñanos J, Vassiliou GS, Saur D, Lohi O, Heinäniemi M, Conte N, Bradley A, Rad L, Rad R. Fischer A, et al. Among authors: klement c. Cell Genom. 2023 Mar 8;3(3):100276. doi: 10.1016/j.xgen.2023.100276. eCollection 2023 Mar 8. Cell Genom. 2023. PMID: 36950387 Free PMC article.
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.
Pedde AM, Kim H, Donakonda S, Baumann T, Bayerl F, Meiser P, Hirschberger A, Klement C, Grassmann S, Öllinger R, Hüser N, Hartmann D, Laschinger M, Trapani JA, Zippelius A, Bald T, Wiedemann GM, Rad R, Sun JC, Höchst B, Böttcher JP. Pedde AM, et al. Among authors: klement c. Cell Rep. 2024 Nov 13;43(11):114855. doi: 10.1016/j.celrep.2024.114855. Online ahead of print. Cell Rep. 2024. PMID: 39541209
42 results