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Page 1
Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.
Gil-Pitarch C, Serrano-Maciá M, Simon J, Mosca L, Conter C, Rejano-Gordillo CM, Zapata-Pavas LE, Peña-Sanfélix P, Azkargorta M, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gómez M, Delgado TC, Porcelli M, Aurrekoetxea I, Sutherland JD, Barrio R, Xirodimas D, Aspichueta P, Elortza F, Martínez-Cruz LA, Nogueiras R, Iruzubieta P, Crespo J, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Mayor U, Goikoetxea-Usandizaga N, González-Recio I, Martínez-Chantar ML. Gil-Pitarch C, et al. Among authors: mercado gomez m. Cell Rep Med. 2024 Jul 16;5(7):101653. doi: 10.1016/j.xcrm.2024.101653. Cell Rep Med. 2024. PMID: 39019009 Free PMC article.
The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.
Mercado-Gómez M, Goikoetxea-Usandizaga N, Kerbert AJC, Gracianteparaluceta LU, Serrano-Maciá M, Lachiondo-Ortega S, Rodriguez-Agudo R, Gil-Pitarch C, Simón J, González-Recio I, Fondevila MF, Santamarina-Ojeda P, Fraga MF, Nogueiras R, Heras JL, Jalan R, Martínez-Chantar ML, Delgado TC. Mercado-Gómez M, et al. Metabolism. 2024 Sep;158:155952. doi: 10.1016/j.metabol.2024.155952. Epub 2024 Jun 19. Metabolism. 2024. PMID: 38906371 Free article.
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1.
Rodríguez-Agudo R, González-Recio I, Serrano-Maciá M, Bravo M, Petrov P, Blaya D, Herranz JM, Mercado-Gómez M, Rejano-Gordillo CM, Lachiondo-Ortega S, Gil-Pitarch C, Azkargorta M, Van Liempd SM, Martinez-Cruz LA, Simão AL, Elortza F, Martín C, Nevzorova YA, Cubero FJ, Delgado TC, Argemi J, Bataller R, Schoonjans K, Banales JM, Castro RE, Sancho-Bru P, Avila MA, Julve J, Jover R, Mabe J, Simon J, Goikoetxea-Usandizaga N, Martínez-Chantar ML. Rodríguez-Agudo R, et al. Among authors: mercado gomez m. JHEP Rep. 2023 Sep 30;6(1):100918. doi: 10.1016/j.jhepr.2023.100918. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38192540 Free PMC article.
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.
Sauve F, Nampoothiri S, Clarke SA, Fernandois D, Ferreira Coêlho CF, Dewisme J, Mills EG, Ternier G, Cotellessa L, Iglesias-Garcia C, Mueller-Fielitz H, Lebouvier T, Perbet R, Florent V, Baroncini M, Sharif A, Ereño-Orbea J, Mercado-Gómez M, Palazon A, Mattot V, Pasquier F, Catteau-Jonard S, Martinez-Chantar M, Hrabovszky E, Jourdain M, Deplanque D, Morelli A, Guarnieri G, Storme L, Robil C, Trottein F, Nogueiras R, Schwaninger M, Pigny P, Poissy J, Chachlaki K, Maurage CA, Giacobini P, Dhillo W, Rasika S, Prevot V. Sauve F, et al. Among authors: mercado gomez m. EBioMedicine. 2023 Oct;96:104784. doi: 10.1016/j.ebiom.2023.104784. Epub 2023 Sep 13. EBioMedicine. 2023. PMID: 37713808 Free PMC article.
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
González-Recio I, Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Mercado-Gómez M, Rodríguez-Agudo R, Lachiondo-Ortega S, Gil-Pitarch C, Fernández-Rodríguez C, Castellana D, Latasa MU, Abecia L, Anguita J, Delgado TC, Iruzubieta P, Crespo J, Hardy S, Petrov PD, Jover R, Avila MA, Martín C, Schaeper U, Tremblay ML, Dear JW, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Buccella D, Martínez-Cruz LA, Martínez-Chantar ML. González-Recio I, et al. Among authors: mercado gomez m. Nat Commun. 2022 Nov 25;13(1):6816. doi: 10.1038/s41467-022-34262-0. Nat Commun. 2022. PMID: 36433951 Free PMC article.
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes.
Mercado-Gómez M, Prieto-Fernández E, Goikoetxea-Usandizaga N, Vila-Vecilla L, Azkargorta M, Bravo M, Serrano-Maciá M, Egia-Mendikute L, Rodríguez-Agudo R, Lachiondo-Ortega S, Lee SY, Eguileor Giné A, Gil-Pitarch C, González-Recio I, Simón J, Petrov P, Jover R, Martínez-Cruz LA, Ereño-Orbea J, Delgado TC, Elortza F, Jiménez-Barbero J, Nogueiras R, Prevot V, Palazon A, Martínez-Chantar ML. Mercado-Gómez M, et al. Commun Biol. 2022 Aug 17;5(1):827. doi: 10.1038/s42003-022-03789-9. Commun Biol. 2022. PMID: 35978143 Free PMC article.
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Tussy P, Fernández-Ramos D, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Mercado-Gómez M, Morán L, Bizkarguenaga M, Lopitz-Otsoa F, Petrov P, Bravo M, Van Liempd SM, Falcon-Perez JM, Zabala-Letona A, Carracedo A, Castell JV, Jover R, Martínez-Cruz LA, Delgado TC, Cubero FJ, Lucena MI, Andrade RJ, Mabe J, Simón J, Martínez-Chantar ML. Rodríguez-Agudo R, et al. Among authors: mercado gomez m. Antioxidants (Basel). 2022 Apr 30;11(5):897. doi: 10.3390/antiox11050897. Antioxidants (Basel). 2022. PMID: 35624761 Free PMC article.
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.
da Silva Lima N, Fondevila MF, Nóvoa E, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R. da Silva Lima N, et al. Among authors: mercado gomez m. J Hepatol. 2022 Jan;76(1):11-24. doi: 10.1016/j.jhep.2021.09.008. Epub 2021 Sep 21. J Hepatol. 2022. PMID: 34555423 Free article.
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals.
Goikoetxea-Usandizaga N, Serrano-Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez-Redondo M, Lachiondo-Ortega S, Rodríguez-Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero-Díaz D, Alfano B, Bravo M, González-Recio I, Mercado-Gómez M, Gil-Pitarch C, Mabe J, Gracia-Sancho J, Abecia L, Lorenzo Ó, Martín-Sanz P, Abrescia NGA, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela-Rey M, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Among authors: mercado gomez m. Hepatology. 2022 Mar;75(3):550-566. doi: 10.1002/hep.32149. Epub 2021 Dec 15. Hepatology. 2022. PMID: 34510498 Free PMC article.
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Serrano-Maciá M, Simón J, González-Rellan MJ, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, De Urturi DS, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Gutiérrez de Juan V, Bizkarguenaga M, Fernández-Ramos D, Buque X, Baselli GA, Valenti LVC, Iruzubieta P, Crespo J, Villa E, Banales JM, Avila MA, Marin JJG, Aspichueta P, Sutherland J, Barrio R, Mayor U, Elortza F, Xirodimas DP, Nogueiras R, Delgado TC, Martínez-Chantar ML. Serrano-Maciá M, et al. Among authors: mercado gomez m. Mol Metab. 2021 Nov;53:101275. doi: 10.1016/j.molmet.2021.101275. Epub 2021 Jun 18. Mol Metab. 2021. PMID: 34153521 Free PMC article.
15 results