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Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Among authors: timpson p. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
FAK signaling in human cancer as a target for therapeutics.
Lee BY, Timpson P, Horvath LG, Daly RJ. Lee BY, et al. Among authors: timpson p. Pharmacol Ther. 2015 Feb;146:132-49. doi: 10.1016/j.pharmthera.2014.10.001. Epub 2014 Oct 12. Pharmacol Ther. 2015. PMID: 25316657 Review.
CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer.
Kalimutho M, Sinha D, Jeffery J, Nones K, Srihari S, Fernando WC, Duijf PH, Vennin C, Raninga P, Nanayakkara D, Mittal D, Saunus JM, Lakhani SR, López JA, Spring KJ, Timpson P, Gabrielli B, Waddell N, Khanna KK. Kalimutho M, et al. Among authors: timpson p. EMBO Mol Med. 2018 Sep;10(9):e8566. doi: 10.15252/emmm.201708566. EMBO Mol Med. 2018. PMID: 30108112 Free PMC article.
Annexin A6 inhibits Ras signalling in breast cancer cells.
Vilá de Muga S, Timpson P, Cubells L, Evans R, Hayes TE, Rentero C, Hegemann A, Reverter M, Leschner J, Pol A, Tebar F, Daly RJ, Enrich C, Grewal T. Vilá de Muga S, et al. Among authors: timpson p. Oncogene. 2009 Jan 22;28(3):363-77. doi: 10.1038/onc.2008.386. Epub 2008 Oct 13. Oncogene. 2009. PMID: 18850003
Annexin A6-A multifunctional scaffold in cell motility.
Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C. Grewal T, et al. Among authors: timpson p. Cell Adh Migr. 2017 May 4;11(3):288-304. doi: 10.1080/19336918.2016.1268318. Epub 2017 Jan 6. Cell Adh Migr. 2017. PMID: 28060548 Free PMC article. Review.
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Samuel MS, et al. Among authors: timpson p. Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008. Cancer Cell. 2011. PMID: 21665151 Free PMC article.
146 results