Jin R - Search Results

1

C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.

Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. Manion J, et al. Among authors: jin r. Nature. 2023 Oct;622(7983):611-618. doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12. Nature. 2023. PMID: 37699522 Free PMC article.

2

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. Yao G, et al. Among authors: jin r. Nat Struct Mol Biol. 2016 Jul;23(7):656-62. doi: 10.1038/nsmb.3245. Epub 2016 Jun 13. Nat Struct Mol Biol. 2016. PMID: 27294781 Free PMC article.

3

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R. Yao G, et al. Among authors: jin r. Sci Rep. 2017 Aug 7;7(1):7438. doi: 10.1038/s41598-017-07457-5. Sci Rep. 2017. PMID: 28785006 Free PMC article.

4

Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Chevalier A, et al. Among authors: jin r. Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27. Nature. 2017. PMID: 28953867 Free PMC article.

5

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.

Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. Chen P, et al. Among authors: jin r. Science. 2018 May 11;360(6389):664-669. doi: 10.1126/science.aar1999. Science. 2018. PMID: 29748286 Free PMC article.

6

Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B.

Chen P, Tao L, Liu Z, Dong M, Jin R. Chen P, et al. Among authors: jin r. FEBS J. 2019 Mar;286(5):874-881. doi: 10.1111/febs.14681. Epub 2018 Nov 1. FEBS J. 2019. PMID: 30347517 Free PMC article. Review.

7

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.

Chen P, Zeng J, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R, Huang L, Dong M, Jin R. Chen P, et al. Among authors: jin r. Nat Commun. 2021 Jun 18;12(1):3748. doi: 10.1038/s41467-021-23878-3. Nat Commun. 2021. PMID: 34145250 Free PMC article.

8

Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B.

Liu Z, Zhang S, Chen P, Tian S, Zeng J, Perry K, Dong M, Jin R. Liu Z, et al. Among authors: jin r. Sci Adv. 2021 Oct 22;7(43):eabi4582. doi: 10.1126/sciadv.abi4582. Epub 2021 Oct 22. Sci Adv. 2021. PMID: 34678063 Free PMC article.

9

Structure and conformational dynamics of Clostridioides difficile toxin A.

Chen B, Basak S, Chen P, Zhang C, Perry K, Tian S, Yu C, Dong M, Huang L, Bowen ME, Jin R. Chen B, et al. Among authors: jin r. Life Sci Alliance. 2022 Mar 15;5(6):e202201383. doi: 10.26508/lsa.202201383. Print 2022 Jun. Life Sci Alliance. 2022. PMID: 35292538 Free PMC article.

10

Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants.

Tian S, Xiong X, Zeng J, Wang S, Tremblay BJ, Chen P, Chen B, Liu M, Chen P, Sheng K, Zeve D, Qi W, Breault DT, Rodríguez C, Gerhard R, Jin R, Doxey AC, Dong M. Tian S, et al. Among authors: jin r. Nat Commun. 2022 Nov 9;13(1):6786. doi: 10.1038/s41467-022-33964-9. Nat Commun. 2022. PMID: 36351897 Free PMC article.

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