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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.
Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. Manion J, et al. Among authors: hurdle jg. Nature. 2023 Oct;622(7983):611-618. doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12. Nature. 2023. PMID: 37699522 Free PMC article.
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.
Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Marreddy RKR, et al. Among authors: hurdle jg. J Biol Chem. 2024 Sep 27;300(11):107839. doi: 10.1016/j.jbc.2024.107839. Online ahead of print. J Biol Chem. 2024. PMID: 39343002 Free PMC article.
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.
Dureja C, Rutherford JT, Pavel FB, Norseeda K, Prah I, Sun D, Hevener KE, Hurdle JG. Dureja C, et al. Among authors: hurdle jg. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0122223. doi: 10.1128/aac.01222-23. Epub 2024 Jan 24. Antimicrob Agents Chemother. 2024. PMID: 38265216 Free PMC article.
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.
Dureja C, Rutherford JT, Pavel FBA, Norseeda K, Prah I, Sun D, Hevener KE, Hurdle JG. Dureja C, et al. Among authors: hurdle jg. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.559005. doi: 10.1101/2023.09.22.559005. bioRxiv. 2023. Update in: Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0122223. doi: 10.1128/aac.01222-23. PMID: 37790427 Free PMC article. Updated. Preprint.
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.
Olaitan AO, Dureja C, Youngblom MA, Topf MA, Shen WJ, Gonzales-Luna AJ, Deshpande A, Hevener KE, Freeman J, Wilcox MH, Palmer KL, Garey KW, Pepperell CS, Hurdle JG. Olaitan AO, et al. Among authors: hurdle jg. Nat Commun. 2023 Jul 12;14(1):4130. doi: 10.1038/s41467-023-39429-x. Nat Commun. 2023. PMID: 37438331 Free PMC article.
61 results