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Page 1
Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.
Li X, Liu J, Boreland AJ, Kapadia S, Zhang S, Stillitano AC, Abbo Y, Clark L, Lai D, Liu Y, Barr PB, Meyers JL, Kamarajan C, Kuang W, Agrawal A, Slesinger PA, Dick D, Salvatore J, Tischfield J, Duan J, Edenberg HJ, Kreimer A, Hart RP, Pang ZP. Li X, et al. Among authors: edenberg hj. Sci Adv. 2024 Nov 8;10(45):eado5820. doi: 10.1126/sciadv.ado5820. Epub 2024 Nov 8. Sci Adv. 2024. PMID: 39514655 Free PMC article.
Concerns about genetic risk testing for opioid use disorder.
Hatoum AS, Davis CN, Kember RL, Johnstone M, Oslin DW, Zinkstok JR, Burmeister M; Ethics, Position, and Public Policy Committee of the International Society of Psychiatric Genetics, Board of Directors of the International Society of Psychiatric Genetics; Agrawal A, Kranzler HR, Edenberg HJ, Gelernter J, Docherty AR, Lencz T. Hatoum AS, et al. Among authors: edenberg hj. Lancet Psychiatry. 2024 Oct 11:S2215-0366(24)00310-9. doi: 10.1016/S2215-0366(24)00310-9. Online ahead of print. Lancet Psychiatry. 2024. PMID: 39413801 No abstract available.
Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder.
Green N, Gao H, Chu X, Yuan Q, McGuire P, Lai D, Jiang G, Xuei X, Reiter JL, Stevens J, Sutherland GT, Goate AM, Pang ZP, Slesinger PA, Hart RP, Tischfield JA, Agrawal A, Wang Y, Duren Z, Edenberg HJ, Liu Y. Green N, et al. Among authors: edenberg hj. bioRxiv [Preprint]. 2024 Oct 31:2024.08.02.606355. doi: 10.1101/2024.08.02.606355. bioRxiv. 2024. PMID: 39149227 Free PMC article. Preprint.
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.
Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Johnson EC, et al. Among authors: edenberg hj. Neuropsychopharmacology. 2024 Oct;49(11):1655-1665. doi: 10.1038/s41386-024-01886-3. Epub 2024 Jun 21. Neuropsychopharmacology. 2024. PMID: 38906991 Free PMC article.
Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans.
Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. Davis CN, et al. Among authors: edenberg hj. medRxiv [Preprint]. 2024 May 16:2024.05.16.24307486. doi: 10.1101/2024.05.16.24307486. medRxiv. 2024. PMID: 38798430 Free PMC article. Preprint.
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.
Daskalakis NP, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, Wylie D, DiPietro CP, Tsatsani I, Chen CY, Pernia CD, Soliva-Estruch M, Arasappan D, Bharadwaj RA, Collado-Torres L, Wuchty S, Alvarez VE, Dammer EB, Deep-Soboslay A, Duong DM, Eagles N, Huber BR, Huuki L, Holstein VL, Logue MW, Lugenbühl JF, Maihofer AX, Miller MW, Nievergelt CM, Pertea G, Ross D, Sendi MSE, Sun BB, Tao R, Tooke J, Wolf EJ, Zeier Z; PTSD Working Group of Psychiatric Genomics Consortium**; Berretta S, Champagne FA, Hyde T, Seyfried NT, Shin JH, Weinberger DR, Nemeroff CB, Kleinman JE, Ressler KJ; PTSD Working Group of Psychiatric Genomics Consortium. Daskalakis NP, et al. Science. 2024 May 24;384(6698):eadh3707. doi: 10.1126/science.adh3707. Epub 2024 May 24. Science. 2024. PMID: 38781393
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R. Paul SE, et al. Among authors: edenberg hj. Psychol Med. 2024 Jul;54(10):2644-2657. doi: 10.1017/S003329172400076X. Epub 2024 May 9. Psychol Med. 2024. PMID: 38721768 Free PMC article.
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovano… See abstract for full author list ➔ Nievergelt CM, et al. Among authors: edenberg hj. Nat Genet. 2024 May;56(5):792-808. doi: 10.1038/s41588-024-01707-9. Epub 2024 Apr 18. Nat Genet. 2024. PMID: 38637617 Free PMC article.
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.
Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS; 23andMe, Inc. Research Team; Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. Jennings MV, et al. Among authors: edenberg hj. EBioMedicine. 2024 May;103:105086. doi: 10.1016/j.ebiom.2024.105086. Epub 2024 Apr 4. EBioMedicine. 2024. PMID: 38580523 Free PMC article.
531 results