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Interleukin-2 superkines by computational design.
Ren J, Chu AE, Jude KM, Picton LK, Kare AJ, Su L, Montano Romero A, Huang PS, Garcia KC. Ren J, et al. Among authors: picton lk. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117401119. doi: 10.1073/pnas.2117401119. Epub 2022 Mar 16. Proc Natl Acad Sci U S A. 2022. PMID: 35294290 Free PMC article.
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. Sockolosky JT, et al. Among authors: picton l. Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246. Science. 2018. PMID: 29496879 Free PMC article.
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance.
Hirai T, Ramos TL, Lin PY, Simonetta F, Su LL, Picton LK, Baker J, Lin JX, Li P, Seo K, Lohmeyer JK, Bolivar-Wagers S, Mavers M, Leonard WJ, Blazar BR, Garcia KC, Negrin RS. Hirai T, et al. Among authors: picton lk. J Clin Invest. 2021 Apr 15;131(8):e139991. doi: 10.1172/JCI139991. J Clin Invest. 2021. PMID: 33855972 Free PMC article.
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. Glassman CR, et al. Among authors: picton lk. Elife. 2021 May 18;10:e65777. doi: 10.7554/eLife.65777. Elife. 2021. PMID: 34003116 Free PMC article.
111 results