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Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy.
Heidegger S, Stritzke F, Dahl S, Daßler-Plenker J, Joachim L, Buschmann D, Fan K, Sauer CM, Ludwig N, Winter C, Enssle S, Li S, Perl M, Görgens A, Haas T, Orberg ET, Göttert S, Wölfel C, Engleitner T, Cortés-Ciriano I, Rad R, Herr W, Giebel B, Ruland J, Bassermann F, Coch C, Hartmann G, Poeck H. Heidegger S, et al. Among authors: coch c. Cell Rep Med. 2023 Sep 19;4(9):101171. doi: 10.1016/j.xcrm.2023.101171. Epub 2023 Aug 31. Cell Rep Med. 2023. PMID: 37657445 Free PMC article.
RIG-I activation induces the release of extracellular vesicles with antitumor activity.
Daßler-Plenker J, Reiners KS, van den Boorn JG, Hansen HP, Putschli B, Barnert S, Schuberth-Wagner C, Schubert R, Tüting T, Hallek M, Schlee M, Hartmann G, Pogge von Strandmann E, Coch C. Daßler-Plenker J, et al. Among authors: coch c. Oncoimmunology. 2016 Aug 19;5(10):e1219827. doi: 10.1080/2162402X.2016.1219827. eCollection 2016. Oncoimmunology. 2016. PMID: 27853642 Free PMC article.
Approaching the RNA ligand for RIG-I?
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G. Schlee M, et al. Among authors: coch c. Immunol Rev. 2009 Jan;227(1):66-74. doi: 10.1111/j.1600-065X.2008.00724.x. Immunol Rev. 2009. PMID: 19120476 Review.
Exosomes as nucleic acid nanocarriers.
van den Boorn JG, Dassler J, Coch C, Schlee M, Hartmann G. van den Boorn JG, et al. Among authors: coch c. Adv Drug Deliv Rev. 2013 Mar;65(3):331-5. doi: 10.1016/j.addr.2012.06.011. Epub 2012 Jun 28. Adv Drug Deliv Rev. 2013. PMID: 22750807 Review.
Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells.
Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G. Coch C, et al. Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019. Front Immunol. 2019. PMID: 30972055 Free PMC article.
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Schlee M, et al. Among authors: coch c. Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. Immunity. 2009. PMID: 19576794 Free PMC article.
72 results