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The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.
Erdem A, Marin S, Pereira-Martins DA, Cortés R, Cunningham A, Pruis MG, de Boer B, van den Heuvel FAJ, Geugien M, Wierenga ATJ, Brouwers-Vos AZ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Among authors: brouwers vos az. Nat Commun. 2022 Mar 1;13(1):1105. doi: 10.1038/s41467-022-28737-3. Nat Commun. 2022. PMID: 35232995 Free PMC article.
The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.
Maat H, Atsma TJ, Hogeling SM, Rodríguez López A, Jaques J, Olthuis M, de Vries MP, Gravesteijn C, Brouwers-Vos AZ, van der Meer N, Datema S, Salzbrunn J, Huls G, Baas R, Martens JHA, van den Boom V, Schuringa JJ. Maat H, et al. Among authors: brouwers vos az. iScience. 2021 Apr 16;24(5):102435. doi: 10.1016/j.isci.2021.102435. eCollection 2021 May 21. iScience. 2021. PMID: 34113809 Free PMC article.
HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells.
Wierenga ATJ, Cunningham A, Erdem A, Lopera NV, Brouwers-Vos AZ, Pruis M, Mulder AB, Günther UL, Martens JHA, Vellenga E, Schuringa JJ. Wierenga ATJ, et al. Among authors: brouwers vos az. Cancer Metab. 2019 Dec 27;7:11. doi: 10.1186/s40170-019-0206-y. eCollection 2019. Cancer Metab. 2019. PMID: 31890203 Free PMC article.
Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.
de Boer B, Prick J, Pruis MG, Keane P, Imperato MR, Jaques J, Brouwers-Vos AZ, Hogeling SM, Woolthuis CM, Nijk MT, Diepstra A, Wandinger S, Versele M, Attar RM, Cockerill PN, Huls G, Vellenga E, Mulder AB, Bonifer C, Schuringa JJ. de Boer B, et al. Among authors: brouwers vos az. Cancer Cell. 2018 Oct 8;34(4):674-689.e8. doi: 10.1016/j.ccell.2018.08.014. Epub 2018 Sep 20. Cancer Cell. 2018. PMID: 30245083 Free article.
Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches.
Antonelli A, Noort WA, Jaques J, de Boer B, de Jong-Korlaar R, Brouwers-Vos AZ, Lubbers-Aalders L, van Velzen JF, Bloem AC, Yuan H, de Bruijn JD, Ossenkoppele GJ, Martens AC, Vellenga E, Groen RW, Schuringa JJ. Antonelli A, et al. Among authors: brouwers vos az. Blood. 2016 Dec 22;128(25):2949-2959. doi: 10.1182/blood-2016-05-719021. Epub 2016 Oct 12. Blood. 2016. PMID: 27733356 Free article.
15 results