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Page 1
EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption.
Pinilla M, Mazars R, Vergé R, Gorse L, Paradis M, Suire B, Santoni K, Robinson KS, Toh GA, Prouvensier L, Leon-Icaza SA, Hessel A, Péricat D, Murris M, Guet-Revillet H, Henras A, Buyck J, Ravet E, Zhong FL, Cougoule C, Planès R, Meunier E. Pinilla M, et al. Among authors: toh ga. J Exp Med. 2023 Oct 2;220(10):e20230104. doi: 10.1084/jem.20230104. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642996 Free PMC article.
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J. Huang M, et al. Among authors: toh ga. Nature. 2021 Apr;592(7856):773-777. doi: 10.1038/s41586-021-03320-w. Epub 2021 Mar 17. Nature. 2021. PMID: 33731929 Free PMC article.
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Among authors: toh ga. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system.
Nadkarni R, Chu WC, Lee CQE, Mohamud Y, Yap L, Toh GA, Beh S, Lim R, Fan YM, Zhang YL, Robinson K, Tryggvason K, Luo H, Zhong F, Ho L. Nadkarni R, et al. Among authors: toh ga. J Exp Med. 2022 Oct 3;219(10):e20212117. doi: 10.1084/jem.20212117. Epub 2022 Sep 21. J Exp Med. 2022. PMID: 36129453 Free PMC article.
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.
Robinson KS, Toh GA, Firdaus MJ, Tham KC, Rozario P, Lim CK, Toh YX, Lau ZH, Binder SC, Mayer J, Bonnard C, Schmidt FI, Common JEA, Zhong FL. Robinson KS, et al. Among authors: toh ga. J Exp Med. 2023 Oct 2;220(10):e20230105. doi: 10.1084/jem.20230105. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642997 Free PMC article.
Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.
Rozario P, Pinilla M, Gorse L, Vind AC, Robinson KS, Toh GA, Firdaus MJ, Martínez JF, Kerk SK, Lin Z, Chambers JC, Bekker-Jensen S, Meunier E, Zhong F. Rozario P, et al. Among authors: toh ga. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309579121. doi: 10.1073/pnas.2309579121. Epub 2024 Jan 4. Proc Natl Acad Sci U S A. 2024. PMID: 38175865 Free PMC article.