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Page 1
Development of a Potent and Selective G2A (GPR132) Agonist.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov VV, Moroz YS, Nevermann S, Mathes M, Ehrler JHM, Alnouri MW, Wolf M, Haydo AS, Schmachtel T, Zaliani A, Höfner G, Kaiser A, Schubert-Zsilavecz M, Beck-Sickinger AG, Offermanns S, Gribbon P, Rieger MA, Merk D, Sisignano M, Steinhilber D, Proschak E. Hernandez-Olmos V, et al. Among authors: steinhilber d. J Med Chem. 2024 Jul 11;67(13):10567-10588. doi: 10.1021/acs.jmedchem.3c02164. Epub 2024 Jun 25. J Med Chem. 2024. PMID: 38917049
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: steinhilber d. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.
Editorial: Lipidomics of oxylipins in biological systems.
Patrignani P, Schebb NH, Werz O, Steinhilber D. Patrignani P, et al. Among authors: steinhilber d. Front Pharmacol. 2023 Dec 6;14:1342596. doi: 10.3389/fphar.2023.1342596. eCollection 2023. Front Pharmacol. 2023. PMID: 38125891 Free PMC article. No abstract available.
Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D, Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC, Freeman BA, Brash AR, FitzGerald GA. O'Donnell VB, et al. Among authors: steinhilber d. Nat Commun. 2023 Nov 9;14(1):7172. doi: 10.1038/s41467-023-41766-w. Nat Commun. 2023. PMID: 37945602 Free PMC article. No abstract available.
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.
Brat C, Huynh Phuoc HP, Awad O, Parmar BS, Hellmuth N, Heinicke U, Amr S, Grimmer J, Sürün D, Husnjak K, Carlsson M, Fahrer J, Bauer T, Krieg SC, Manolikakes G, Zacharowski K, Steinhilber D, Münch C, Maier TJ, Roos J. Brat C, et al. Among authors: steinhilber d. Cell Chem Biol. 2023 Oct 19;30(10):1277-1294.e12. doi: 10.1016/j.chembiol.2023.06.017. Epub 2023 Jul 19. Cell Chem Biol. 2023. PMID: 37473760 Free article.
309 results