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Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL, Leschziner AE. Karasmanis EP, et al. Among authors: reimer jm. Nat Struct Mol Biol. 2023 Sep;30(9):1357-1364. doi: 10.1038/s41594-023-01069-6. Epub 2023 Aug 24. Nat Struct Mol Biol. 2023. PMID: 37620585 Free PMC article.
Structure of LRRK1 and mechanisms of autoinhibition and activation.
Reimer JM, Dickey AM, Lin YX, Abrisch RG, Mathea S, Chatterjee D, Fay EJ, Knapp S, Daugherty MD, Reck-Peterson SL, Leschziner AE. Reimer JM, et al. Nat Struct Mol Biol. 2023 Nov;30(11):1735-1745. doi: 10.1038/s41594-023-01109-1. Epub 2023 Oct 19. Nat Struct Mol Biol. 2023. PMID: 37857821 Free PMC article.
A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial.
Alkema M, Smit MJ, Marin-Mogollon C, Totté K, Teelen K, van Gemert GJ, van de Vegte-Bolmer M, Mordmüller BG, Reimer JM, Lövgren-Bengtsson KL, Sauerwein RW, Bousema T, Plieskatt J, Theisen M, Jore MM, McCall MBB. Alkema M, et al. Among authors: reimer jm. BMC Med. 2024 Apr 23;22(1):170. doi: 10.1186/s12916-024-03379-y. BMC Med. 2024. PMID: 38649867 Free PMC article. Clinical Trial.
A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults.
Tiono AB, Plieskatt JL, Ouedraogo A, Soulama BI, Miura K, Bougouma EC, Naghizadeh M, Barry A, Yaro JBB, Ezinmegnon S, Henry N, Ofori EA, Adu B, Singh SK, Konkobo A, Lövgren Bengtsson K, Diarra A, Carnrot C, Reimer JM, Ouedraogo A, Tienta M, Long CA, Ouedraogo IN, Sagara I, Sirima SB, Theisen M. Tiono AB, et al. Among authors: reimer jm. J Clin Invest. 2024 Apr 1;134(7):e175707. doi: 10.1172/JCI175707. J Clin Invest. 2024. PMID: 38290009 Free PMC article. Clinical Trial.
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.
Martinez FJ, White M, Guillotte-Blisnick M, Huon C, Boucharlat A, Agou F, England P, Popovici J, Hou MM, Silk SE, Barrett JR, Nielsen CM, Reimer JM, Mukherjee P, Chauhan VS, Minassian AM, Draper SJ, Chitnis CE. Martinez FJ, et al. Among authors: reimer jm. NPJ Vaccines. 2024 Jan 6;9(1):10. doi: 10.1038/s41541-023-00796-7. NPJ Vaccines. 2024. PMID: 38184681 Free PMC article.
Immunogenicity of a Plasmodium vivax vaccine based on the duffy binding protein formulated using adjuvants compatible for use in humans.
Martinez FJ, Guillotte-Blisnick M, Huon C, England P, Popovici J, Laude H, Arowas L, Ungeheuer MN, Reimer JM, Carter D, Reed S, Mukherjee P, Chauhan VS, Chitnis CE. Martinez FJ, et al. Among authors: reimer jm. Sci Rep. 2023 Aug 25;13(1):13904. doi: 10.1038/s41598-023-40043-6. Sci Rep. 2023. PMID: 37626150 Free PMC article.
Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection.
Hou MM, Barrett JR, Themistocleous Y, Rawlinson TA, Diouf A, Martinez FJ, Nielsen CM, Lias AM, King LDW, Edwards NJ, Greenwood NM, Kingham L, Poulton ID, Khozoee B, Goh C, Hodgson SH, Mac Lochlainn DJ, Salkeld J, Guillotte-Blisnick M, Huon C, Mohring F, Reimer JM, Chauhan VS, Mukherjee P, Biswas S, Taylor IJ, Lawrie AM, Cho JS, Nugent FL, Long CA, Moon RW, Miura K, Silk SE, Chitnis CE, Minassian AM, Draper SJ. Hou MM, et al. Among authors: reimer jm. Sci Transl Med. 2023 Jul 12;15(704):eadf1782. doi: 10.1126/scitranslmed.adf1782. Epub 2023 Jul 12. Sci Transl Med. 2023. PMID: 37437014 Free PMC article.
62 results