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Page 1
Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters.
Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW. Kulkarni CP, et al. Among authors: koleske ml. Pharmaceutics. 2024 May 10;16(5):647. doi: 10.3390/pharmaceutics16050647. Pharmaceutics. 2024. PMID: 38794309 Free PMC article.
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki JE, Capra JA, Artursson P, Newman JW, Marquès-Bonet T, Giacomini KM. Yee SW, et al. Among authors: koleske ml. Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7. Nat Commun. 2024. PMID: 38782905 Free PMC article.
The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
Yee SW, Macdonald CB, Mitrovic D, Zhou X, Koleske ML, Yang J, Buitrago Silva D, Rockefeller Grimes P, Trinidad DD, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. Yee SW, et al. Among authors: koleske ml. Mol Cell. 2024 May 16;84(10):1932-1947.e10. doi: 10.1016/j.molcel.2024.04.008. Epub 2024 May 3. Mol Cell. 2024. PMID: 38703769
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. Yee SW, et al. Among authors: koleske ml. Res Sq [Preprint]. 2023 Sep 14:rs.3.rs-3263845. doi: 10.21203/rs.3.rs-3263845/v1. Res Sq. 2023. Update in: Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7 PMID: 37790518 Free PMC article. Updated. Preprint.
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. Yee SW, et al. Among authors: koleske ml. bioRxiv [Preprint]. 2023 Aug 12:2023.08.08.552553. doi: 10.1101/2023.08.08.552553. bioRxiv. 2023. Update in: Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7 PMID: 37609337 Free PMC article. Updated. Preprint.
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. Yee SW, et al. Among authors: koleske ml. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543963. doi: 10.1101/2023.06.06.543963. bioRxiv. 2023. Update in: Mol Cell. 2024 May 16;84(10):1932-1947.e10. doi: 10.1016/j.molcel.2024.04.008 PMID: 37333090 Free PMC article. Updated. Preprint.
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. Koleske ML, et al. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2210247119. doi: 10.1073/pnas.2210247119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343260 Free PMC article.
New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. Giacomini KM, et al. Among authors: koleske ml. Clin Pharmacol Ther. 2022 Sep;112(3):540-561. doi: 10.1002/cpt.2627. Epub 2022 May 20. Clin Pharmacol Ther. 2022. PMID: 35488474 Free PMC article. Review.
16 results