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Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT. Gu J, et al. Among authors: ciccia a. Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02386-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39375448
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.
Chen X, Li Y, Zhu F, Xu X, Estrella B, Pazos MA 2nd, McGuire JT, Karagiannis D, Sahu V, Mustafokulov M, Scuoppo C, Sánchez-Rivera FJ, Soto-Feliciano YM, Pasqualucci L, Ciccia A, Amengual JE, Lu C. Chen X, et al. Among authors: ciccia a. Nat Commun. 2023 Jul 17;14(1):4259. doi: 10.1038/s41467-023-39990-5. Nat Commun. 2023. PMID: 37460547 Free PMC article.
Mechanism of DNA unwinding by MCM8-9 in complex with HROB.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling VM, Seidel R, Ciccia A, Guérois R, Cejka P. Acharya A, et al. Among authors: ciccia a. Nat Commun. 2024 Apr 27;15(1):3584. doi: 10.1038/s41467-024-47936-8. Nat Commun. 2024. PMID: 38678026 Free PMC article.
The DNA Damage Response and Inflammation in Cancer.
Klapp V, Álvarez-Abril B, Leuzzi G, Kroemer G, Ciccia A, Galluzzi L. Klapp V, et al. Among authors: ciccia a. Cancer Discov. 2023 Jul 7;13(7):1521-1545. doi: 10.1158/2159-8290.CD-22-1220. Cancer Discov. 2023. PMID: 37026695
92 results