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RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin-proteasome pathway contributes to the reversion of ATRA resistance.
Yan W, Li J, Zhang Y, Yin Y, Cheng Z, Wang J, Hu G, Liu S, Wang Y, Xu Y, Peng H, Zhang G. Yan W, et al. Among authors: cheng z. Cancer Cell Int. 2019 Apr 4;19:84. doi: 10.1186/s12935-019-0803-4. eCollection 2019. Cancer Cell Int. 2019. PMID: 30992691 Free PMC article.
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