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APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.
Chemparathy A, Guen YL, Chen S, Lee EG, Leong L, Gorzynski J, Xu G, Belloy M, Kasireddy N, Tauber AP, Williams K, Stewart I, Wingo T, Lah J, Jayadev S, Hales C, Peskind E, Child DD, Keene CD, Cong L, Ashley E, Yu CE, Greicius MD. Chemparathy A, et al. Among authors: leong l. medRxiv [Preprint]. 2023 Jul 24:2023.07.20.23292771. doi: 10.1101/2023.07.20.23292771. medRxiv. 2023. Update in: Neuron. 2024 Apr 3;112(7):1110-1116.e5. doi: 10.1016/j.neuron.2024.01.008. PMID: 37547016 Free PMC article. Updated. Preprint.
Epigenetic signature and enhancer activity of the human APOE gene.
Yu CE, Cudaback E, Foraker J, Thomson Z, Leong L, Lutz F, Gill JA, Saxton A, Kraemer B, Navas P, Keene CD, Montine T, Bekris LM. Yu CE, et al. Among authors: leong l. Hum Mol Genet. 2013 Dec 15;22(24):5036-47. doi: 10.1093/hmg/ddt354. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23892237 Free PMC article.
The APOE Gene is Differentially Methylated in Alzheimer's Disease.
Foraker J, Millard SP, Leong L, Thomson Z, Chen S, Keene CD, Bekris LM, Yu CE. Foraker J, et al. Among authors: leong l. J Alzheimers Dis. 2015;48(3):745-55. doi: 10.3233/JAD-143060. J Alzheimers Dis. 2015. PMID: 26402071 Free PMC article.
APOE DNA methylation is altered in Lewy body dementia.
Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D. Tulloch J, et al. Among authors: leong l. Alzheimers Dement. 2018 Jul;14(7):889-894. doi: 10.1016/j.jalz.2018.02.005. Epub 2018 Mar 12. Alzheimers Dement. 2018. PMID: 29544979 Free PMC article.
Glia-specific APOE epigenetic changes in the Alzheimer's disease brain.
Tulloch J, Leong L, Thomson Z, Chen S, Lee EG, Keene CD, Millard SP, Yu CE. Tulloch J, et al. Among authors: leong l. Brain Res. 2018 Nov 1;1698:179-186. doi: 10.1016/j.brainres.2018.08.006. Epub 2018 Aug 3. Brain Res. 2018. PMID: 30081037 Free PMC article.
471 results