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Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. Castiglioni A, et al. Among authors: mellman i. Nat Commun. 2023 Aug 5;14(1):4703. doi: 10.1038/s41467-023-40398-4. Nat Commun. 2023. PMID: 37543621 Free PMC article.
Antigen processing for amateurs and professionals.
Mellman I, Turley SJ, Steinman RM. Mellman I, et al. Trends Cell Biol. 1998 Jun;8(6):231-7. doi: 10.1016/s0962-8924(98)01276-8. Trends Cell Biol. 1998. PMID: 9695847 Free article. Review.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS. Herbst RS, et al. Among authors: mellman i. Nature. 2014 Nov 27;515(7528):563-7. doi: 10.1038/nature14011. Nature. 2014. PMID: 25428504 Free PMC article. Clinical Trial.
High cell-surface density of HER2 deforms cell membranes.
Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX. Chung I, et al. Among authors: mellman i. Nat Commun. 2016 Sep 7;7:12742. doi: 10.1038/ncomms12742. Nat Commun. 2016. PMID: 27599456 Free PMC article.
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.
Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K, Sanders L, Koeppen H, Caplazi P, McBride J, Chiu H, Hong R, Grogan J, Javinal V, Yauch R, Irving B, Belvin M, Mellman I, Kim JM, Schmidt M. Lau J, et al. Among authors: mellman i. Nat Commun. 2017 Feb 21;8:14572. doi: 10.1038/ncomms14572. Nat Commun. 2017. PMID: 28220772 Free PMC article.
310 results