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Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho HS, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn RA, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: cho hs. Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. Epub 2023 Jul 24. Nat Genet. 2023. PMID: 37488417 Free PMC article.
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant.
Kaplan SJ, Wong W, Yan J, Pulecio J, Cho HS, Li Q, Zhao J, Leslie-Iyer J, Kazakov J, Murphy D, Luo R, Dey KK, Apostolou E, Leslie CS, Huangfu D. Kaplan SJ, et al. Among authors: cho hs. bioRxiv [Preprint]. 2024 Jun 28:2024.04.26.591412. doi: 10.1101/2024.04.26.591412. bioRxiv. 2024. Update in: Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640 PMID: 38746154 Free PMC article. Updated. Preprint.
An epigenetic barrier sets the timing of human neuronal maturation.
Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. Ciceri G, et al. Among authors: cho hs. Nature. 2024 Feb;626(8000):881-890. doi: 10.1038/s41586-023-06984-8. Epub 2024 Jan 31. Nature. 2024. PMID: 38297124 Free PMC article.
TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons.
Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. Kim TW, et al. Among authors: cho hs. Cell. 2024 Jul 11;187(14):3671-3689.e23. doi: 10.1016/j.cell.2024.05.030. Epub 2024 Jun 11. Cell. 2024. PMID: 38866017 Free article.
1,187 results