Tagaya Y - Search Results

1

Effective treatment with the selective cytokine inhibitor BNZ-1 reveals the cytokine dependency of T-LGL leukemia.

Brammer JE, Ballen K, Sokol L, Querfeld C, Nakamura R, Mishra A, McLaughlin EM, Feith D, Azimi N, Waldmann TA, Tagaya Y, Loughran T. Brammer JE, et al. Among authors: tagaya y. Blood. 2023 Oct 12;142(15):1271-1280. doi: 10.1182/blood.2022017643. Blood. 2023. PMID: 37352612 Free PMC article. Clinical Trial.

2

Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.

Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, Tagaya Y. Kobayashi H, et al. Among authors: tagaya y. Blood. 2005 Jan 15;105(2):721-7. doi: 10.1182/blood-2003-12-4187. Epub 2004 Sep 14. Blood. 2005. PMID: 15367431 Free article.

3

Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.

Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y. Sato N, et al. Among authors: tagaya y. Blood. 2011 Apr 14;117(15):4032-40. doi: 10.1182/blood-2010-09-307504. Epub 2011 Feb 8. Blood. 2011. PMID: 21304101 Free PMC article.

4

IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability.

Wang TT, Yang J, Zhang Y, Zhang M, Dubois S, Conlon KC, Tagaya Y, Hamele CE, Dighe S, Olson TL, Feith DJ, Azimi N, Waldmann TA, Loughran TP Jr. Wang TT, et al. Among authors: tagaya y. Leukemia. 2019 May;33(5):1243-1255. doi: 10.1038/s41375-018-0290-y. Epub 2018 Oct 23. Leukemia. 2019. PMID: 30353031 Free PMC article.

5

Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines.

Frohna PA, Ratnayake A, Doerr N, Basheer A, Al-Mawsawi LQ, Kim WJ, Zapata JC, Wu X, Waldmann TA, Azimi N, Tagaya Y. Frohna PA, et al. Among authors: tagaya y. J Clin Pharmacol. 2020 Feb;60(2):264-273. doi: 10.1002/jcph.1522. Epub 2019 Aug 29. J Clin Pharmacol. 2020. PMID: 31465127 Free PMC article. Clinical Trial.

6

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.

Ju W, Zhang M, Jiang JK, Thomas CJ, Oh U, Bryant BR, Chen J, Sato N, Tagaya Y, Morris JC, Janik JE, Jacobson S, Waldmann TA. Ju W, et al. Among authors: tagaya y. Blood. 2011 Feb 10;117(6):1938-46. doi: 10.1182/blood-2010-09-305425. Epub 2010 Nov 24. Blood. 2011. PMID: 21106989 Free PMC article.

7

The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens.

Waldmann TA, Tagaya Y. Waldmann TA, et al. Among authors: tagaya y. Annu Rev Immunol. 1999;17:19-49. doi: 10.1146/annurev.immunol.17.1.19. Annu Rev Immunol. 1999. PMID: 10358752 Review.

8

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

Sato N, Patel HJ, Waldmann TA, Tagaya Y. Sato N, et al. Among authors: tagaya y. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):588-93. doi: 10.1073/pnas.0610115104. Epub 2007 Jan 3. Proc Natl Acad Sci U S A. 2007. PMID: 17202253 Free PMC article.

9

Accessory cells precondition naïve T cells and regulatory T cells for cytokine-mediated proliferation.

Sato N, Bamford RN, Bryant BR, Tagaya Y, Waldmann TA. Sato N, et al. Among authors: tagaya y. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2217562120. doi: 10.1073/pnas.2217562120. Epub 2023 Apr 4. Proc Natl Acad Sci U S A. 2023. PMID: 37014858 Free PMC article.

10

Interleukin-2, interleukin-15, and their receptors.

Waldmann T, Tagaya Y, Bamford R. Waldmann T, et al. Among authors: tagaya y. Int Rev Immunol. 1998;16(3-4):205-26. doi: 10.3109/08830189809042995. Int Rev Immunol. 1998. PMID: 9505189 Review.

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