Liu DR - Search Results

1

Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos.

Chen L, Hong M, Luan C, Gao H, Ru G, Guo X, Zhang D, Zhang S, Li C, Wu J, Randolph PB, Sousa AA, Qu C, Zhu Y, Guan Y, Wang L, Liu M, Feng B, Song G, Liu DR, Li D. Chen L, et al. Among authors: liu m, liu dr. Nat Biotechnol. 2024 Apr;42(4):638-650. doi: 10.1038/s41587-023-01821-9. Epub 2023 Jun 15. Nat Biotechnol. 2024. PMID: 37322276

2

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity.

Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA, Liu DR. Pattanayak V, et al. Among authors: liu dr. Nat Biotechnol. 2013 Sep;31(9):839-43. doi: 10.1038/nbt.2673. Epub 2013 Aug 11. Nat Biotechnol. 2013. PMID: 23934178 Free PMC article.

3

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification.

Guilinger JP, Thompson DB, Liu DR. Guilinger JP, et al. Among authors: liu dr. Nat Biotechnol. 2014 Jun;32(6):577-582. doi: 10.1038/nbt.2909. Epub 2014 Apr 25. Nat Biotechnol. 2014. PMID: 24770324 Free PMC article.

4

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.

Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR. Zuris JA, et al. Among authors: liu dr. Nat Biotechnol. 2015 Jan;33(1):73-80. doi: 10.1038/nbt.3081. Epub 2014 Oct 30. Nat Biotechnol. 2015. PMID: 25357182 Free PMC article.

5

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.

Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Komor AC, et al. Among authors: liu dr. Nature. 2016 May 19;533(7603):420-4. doi: 10.1038/nature17946. Epub 2016 Apr 20. Nature. 2016. PMID: 27096365 Free PMC article.

6

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.

Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. Kim YB, et al. Among authors: liu dr. Nat Biotechnol. 2017 Apr;35(4):371-376. doi: 10.1038/nbt.3803. Epub 2017 Feb 13. Nat Biotechnol. 2017. PMID: 28191901 Free PMC article.

7

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation.

Tang W, Hu JH, Liu DR. Tang W, et al. Among authors: liu dr. Nat Commun. 2017 Jun 28;8:15939. doi: 10.1038/ncomms15939. Nat Commun. 2017. PMID: 28656978 Free PMC article.

8

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.

Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Gaudelli NM, et al. Among authors: liu dr. Nature. 2017 Nov 23;551(7681):464-471. doi: 10.1038/nature24644. Epub 2017 Oct 25. Nature. 2017. PMID: 29160308 Free PMC article.

9

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Gao X, et al. Among authors: liu dr. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. Nature. 2018. PMID: 29258297 Free PMC article.

10

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.

Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR. Hu JH, et al. Among authors: liu dr. Nature. 2018 Apr 5;556(7699):57-63. doi: 10.1038/nature26155. Epub 2018 Feb 28. Nature. 2018. PMID: 29512652 Free PMC article.

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