Nomura DK - Search Results

1

N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics.

Koo TY, Lai H, Nomura DK, Chung CY. Koo TY, et al. Among authors: nomura dk. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Nat Commun. 2023. PMID: 37322008 Free PMC article.

2

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.

Bateman LA, Nguyen TB, Roberts AM, Miyamoto DK, Ku WM, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA, Nomura DK. Bateman LA, et al. Among authors: nomura dk. Chem Commun (Camb). 2017 Jun 29;53(53):7234-7237. doi: 10.1039/c7cc01480e. Chem Commun (Camb). 2017. PMID: 28352901 Free PMC article.

3

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK. Ward CC, et al. Among authors: nomura dk. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13. ACS Chem Biol. 2019. PMID: 31059647 Free PMC article.

4

Covalent targeting of the vacuolar H⁺-ATPase activates autophagy via mTORC1 inhibition.

Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. Chung CY, et al. Among authors: nomura dk. Nat Chem Biol. 2019 Aug;15(8):776-785. doi: 10.1038/s41589-019-0308-4. Epub 2019 Jul 8. Nat Chem Biol. 2019. PMID: 31285595 Free PMC article.

5

Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots.

Roberts AM, Ward CC, Nomura DK. Roberts AM, et al. Among authors: nomura dk. Curr Opin Biotechnol. 2017 Feb;43:25-33. doi: 10.1016/j.copbio.2016.08.003. Epub 2016 Aug 26. Curr Opin Biotechnol. 2017. PMID: 27568596 Free PMC article. Review.

6

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.

Ward CC, Kleinman JI, Nomura DK. Ward CC, et al. Among authors: nomura dk. ACS Chem Biol. 2017 Jun 16;12(6):1478-1483. doi: 10.1021/acschembio.7b00125. Epub 2017 May 1. ACS Chem Biol. 2017. PMID: 28445029 Free PMC article.

7

Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R. Gibeaux R, et al. Among authors: nomura dk. Nature. 2018 Jan 18;553(7688):337-341. doi: 10.1038/nature25188. Epub 2018 Jan 10. Nature. 2018. PMID: 29320479 Free PMC article.

8

Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC.

Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Boike L, et al. Among authors: nomura dk. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22. Cell Chem Biol. 2021. PMID: 32966806 Free PMC article.

9

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.

Zhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, Abbasi F, Ronquillo E, Scheker K, Muñoz A, Kuang YL, Theusch E, Lu M, Sanchez G, Oni-Orisan A, Iribarren C, McPhaul MJ, Nomura DK, Knowles JW, Krauss RM, Medina MW, Reue K. Zhang P, et al. Among authors: nomura dk. Nat Commun. 2024 Jul 2;15(1):5571. doi: 10.1038/s41467-024-49764-2. Nat Commun. 2024. PMID: 38956041 Free PMC article.

10

Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK. Grossman EA, et al. Among authors: nomura dk. Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4. doi: 10.1016/j.chembiol.2017.08.013. Epub 2017 Sep 14. Cell Chem Biol. 2017. PMID: 28919038 Free PMC article.

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