Amrhein JA - Search Results

1

Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.

Amrhein JA, Wang G, Berger BT, Berger LM, Kalampaliki AD, Krämer A, Knapp S, Hanke T. Amrhein JA, et al. ACS Med Chem Lett. 2023 May 30;14(6):833-840. doi: 10.1021/acsmedchemlett.3c00127. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312836 Free PMC article.

2

Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.

Amrhein JA, Knapp S, Hanke T. Amrhein JA, et al. J Med Chem. 2021 Jun 24;64(12):7991-8009. doi: 10.1021/acs.jmedchem.1c00217. Epub 2021 Jun 2. J Med Chem. 2021. PMID: 34076436 Review.

3

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, Mathea S, Berger LM, Berger BT, Krämer A, Weller M, Weiss T, Müller S, Knapp S, Hanke T. Kurz CG, et al. Among authors: amrhein ja. J Med Chem. 2022 Jun 9;65(11):7799-7817. doi: 10.1021/acs.jmedchem.2c00173. Epub 2022 May 24. J Med Chem. 2022. PMID: 35608370

4

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.

Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Amrhein JA, et al. J Med Chem. 2022 Dec 8;65(23):15679-15697. doi: 10.1021/acs.jmedchem.2c01041. Epub 2022 Nov 16. J Med Chem. 2022. PMID: 36384036 Free PMC article.

5

Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family.

Amrhein JA, Berger LM, Tjaden A, Krämer A, Elson L, Tolvanen T, Martinez-Molina D, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T. Amrhein JA, et al. Int J Mol Sci. 2022 Nov 27;23(23):14834. doi: 10.3390/ijms232314834. Int J Mol Sci. 2022. PMID: 36499165 Free PMC article.

6

Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.

Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, Frischkorn JM, Berger BT, Elson L, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T. Amrhein JA, et al. J Med Chem. 2024 Jan 11;67(1):674-690. doi: 10.1021/acs.jmedchem.3c01980. Epub 2023 Dec 21. J Med Chem. 2024. PMID: 38126712

7

Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.

Salas-Lucia F, França MM, Amrhein JA, Weir JE, Dumitrescu AM, Refetoff S. Salas-Lucia F, et al. Among authors: amrhein ja. Thyroid. 2022 Mar;32(3):336-339. doi: 10.1089/thy.2021.0523. Thyroid. 2022. PMID: 34969265 Free PMC article.

8

The role of the sex-determining region Y gene in the etiology of 46,XX maleness.

Fechner PY, Marcantonio SM, Jaswaney V, Stetten G, Goodfellow PN, Migeon CJ, Smith KD, Berkovitz GD, Amrhein JA, Bard PA, et al. Fechner PY, et al. Among authors: amrhein ja. J Clin Endocrinol Metab. 1993 Mar;76(3):690-5. doi: 10.1210/jcem.76.3.8383144. J Clin Endocrinol Metab. 1993. PMID: 8383144

9

A clinical syndrome of mild androgen insensitivity.

Migeon CJ, Brown TR, Lanes R, Palacios A, Amrhein JA, Schoen EJ. Migeon CJ, et al. Among authors: amrhein ja. J Clin Endocrinol Metab. 1984 Oct;59(4):672-8. doi: 10.1210/jcem-59-4-672. J Clin Endocrinol Metab. 1984. PMID: 6434576

10

17 alpha-hydroxylase deficiency in a genetic male and female sibling pair.

Sills IN, MacGillivray MH, Amrhein JA, Migeon CJ, Peterson RE. Sills IN, et al. Among authors: amrhein ja. Int J Gynaecol Obstet. 1981 Dec;19(6):473-9. doi: 10.1016/0020-7292(81)90007-2. Int J Gynaecol Obstet. 1981. PMID: 6121730

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