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Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells.
Haas AR, Golden RJ, Litzky LA, Engels B, Zhao L, Xu F, Taraszka JA, Ramones M, Granda B, Chang WJ, Jadlowsky J, Shea KM, Runkle A, Chew A, Dowd E, Gonzalez V, Chen F, Liu X, Fang C, Jiang S, Davis MM, Sheppard NC, Zhao Y, Fraietta JA, Lacey SF, Plesa G, Melenhorst JJ, Mansfield K, Brogdon JL, Young RM, Albelda SM, June CH, Tanyi JL. Haas AR, et al. Among authors: zhao y, zhao l. Mol Ther. 2023 Aug 2;31(8):2309-2325. doi: 10.1016/j.ymthe.2023.06.006. Epub 2023 Jun 12. Mol Ther. 2023. PMID: 37312454 Free PMC article.
Treatment of advanced leukemia in mice with mRNA engineered T cells.
Barrett DM, Zhao Y, Liu X, Jiang S, Carpenito C, Kalos M, Carroll RG, June CH, Grupp SA. Barrett DM, et al. Among authors: zhao y. Hum Gene Ther. 2011 Dec;22(12):1575-86. doi: 10.1089/hum.2011.070. Epub 2011 Sep 23. Hum Gene Ther. 2011. PMID: 21838572 Free PMC article.
TCR affinity and specificity requirements for human regulatory T-cell function.
Plesa G, Zheng L, Medvec A, Wilson CB, Robles-Oteiza C, Liddy N, Bennett AD, Gavarret J, Vuidepot A, Zhao Y, Blazar BR, Jakobsen BK, Riley JL. Plesa G, et al. Among authors: zhao y. Blood. 2012 Apr 12;119(15):3420-30. doi: 10.1182/blood-2011-09-377051. Epub 2012 Feb 7. Blood. 2012. PMID: 22318202 Free PMC article.
Adoptive immunotherapy for cancer or viruses.
Maus MV, Fraietta JA, Levine BL, Kalos M, Zhao Y, June CH. Maus MV, et al. Among authors: zhao y. Annu Rev Immunol. 2014;32:189-225. doi: 10.1146/annurev-immunol-032713-120136. Epub 2014 Jan 9. Annu Rev Immunol. 2014. PMID: 24423116 Free PMC article. Review.
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH. Maus MV, et al. Among authors: zhao y. Cancer Immunol Res. 2013 Jul;1(1):26-31. doi: 10.1158/2326-6066.CIR-13-0006. Epub 2013 Apr 7. Cancer Immunol Res. 2013. PMID: 24777247 Free PMC article. Clinical Trial.
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