Yuen SL - Search Results

1

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin.

Muretta JM, Rajasekaran D, Blat Y, Little S, Myers M, Nair C, Burdekin B, Yuen SL, Jimenez N, Guhathakurta P, Wilson A, Thompson AR, Surti N, Connors D, Chase P, Harden D, Barbieri CM, Adam L, Thomas DD. Muretta JM, et al. Among authors: yuen sl. SLAS Discov. 2023 Jul;28(5):223-232. doi: 10.1016/j.slasd.2023.06.001. Epub 2023 Jun 10. SLAS Discov. 2023. PMID: 37307989 Free PMC article.

2

High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA.

Schaaf TM, Peterson KC, Grant BD, Bawaskar P, Yuen S, Li J, Muretta JM, Gillispie GD, Thomas DD. Schaaf TM, et al. SLAS Discov. 2017 Mar;22(3):262-273. doi: 10.1177/1087057116680151. Epub 2016 Dec 13. SLAS Discov. 2017. PMID: 27899691 Free PMC article.

3

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells.

Stroik DR, Yuen SL, Janicek KA, Schaaf TM, Li J, Ceholski DK, Hajjar RJ, Cornea RL, Thomas DD. Stroik DR, et al. Among authors: yuen sl. Sci Rep. 2018 Aug 22;8(1):12560. doi: 10.1038/s41598-018-29685-z. Sci Rep. 2018. PMID: 30135432 Free PMC article.

4

Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening.

Schaaf TM, Li A, Grant BD, Peterson K, Yuen S, Bawaskar P, Kleinboehl E, Li J, Thomas DD, Gillispie GD. Schaaf TM, et al. Biosensors (Basel). 2018 Oct 24;8(4):99. doi: 10.3390/bios8040099. Biosensors (Basel). 2018. PMID: 30352972 Free PMC article.

5

Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca²⁺ Transport.

Schaaf TM, Kleinboehl E, Yuen SL, Roelike LN, Svensson B, Thompson AR, Cornea RL, Thomas DD. Schaaf TM, et al. Among authors: yuen sl. Cells. 2020 May 8;9(5):1170. doi: 10.3390/cells9051170. Cells. 2020. PMID: 32397211 Free PMC article.

6

The transmembrane peptide DWORF activates SERCA2a via dual mechanisms.

Li A, Yuen SL, Stroik DR, Kleinboehl E, Cornea RL, Thomas DD. Li A, et al. Among authors: yuen sl. J Biol Chem. 2021 Jan-Jun;296:100412. doi: 10.1016/j.jbc.2021.100412. Epub 2021 Feb 11. J Biol Chem. 2021. PMID: 33581112 Free PMC article.

7

A Large-Scale High-Throughput Screen for Modulators of SERCA Activity.

Bidwell PA, Yuen SL, Li J, Berg K, Rebbeck RT, Aldrich CC, Roopnarine O, Cornea RL, Thomas DD. Bidwell PA, et al. Among authors: yuen sl. Biomolecules. 2022 Nov 30;12(12):1789. doi: 10.3390/biom12121789. Biomolecules. 2022. PMID: 36551215 Free PMC article.

8

Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells.

Young MC, Vunnam N, Rebbeck RT, Yuen SL, Thomas DD, Sachs JN. Young MC, et al. Among authors: yuen sl. Nat Prod Commun. 2023 Jan;18(1):10.1177/1934578x221144580. doi: 10.1177/1934578x221144580. Epub 2023 Jan 11. Nat Prod Commun. 2023. PMID: 37063699 Free PMC article.

9

Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators.

Roopnarine O, Yuen SL, Thompson AR, Roelike LN, Rebbeck RT, Bidwell PA, Aldrich CC, Cornea RL, Thomas DD. Roopnarine O, et al. Among authors: yuen sl. Sci Rep. 2023 Jul 1;13(1):10673. doi: 10.1038/s41598-023-37704-x. Sci Rep. 2023. PMID: 37393380 Free PMC article.

10

Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein.

Braun AR, Kochen NN, Yuen SL, Liao EE, Cornea RL, Thomas DD, Sachs JN. Braun AR, et al. Among authors: yuen sl. ASN Neuro. 2023 Jan-Dec;15:17590914231184086. doi: 10.1177/17590914231184086. ASN Neuro. 2023. PMID: 37428128 Free PMC article.

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