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GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.
Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu TW, Ramsamooj S, Grover R, Hwang SK, Ngo B, Cantley LC, Rhee KY, Goncalves MD. Liang RJ, et al. Among authors: goncalves md. Cancer Metab. 2021 Mar 24;9(1):12. doi: 10.1186/s40170-021-00246-9. Cancer Metab. 2021. PMID: 33762003 Free PMC article.
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer.
Queiroz AL, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica ERM, Liang RJ, Murphy J, Holman CD, Bare CJ, Ghahramani G, Wu Z, Cohen DE, Kirwan JP, Cantley LC, Axelrod CL, Goncalves MD. Queiroz AL, et al. Among authors: goncalves md. Nat Commun. 2022 Aug 8;13(1):4633. doi: 10.1038/s41467-022-32135-0. Nat Commun. 2022. PMID: 35941104 Free PMC article.
Cachexia: A systemic consequence of progressive, unresolved disease.
Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O'Rahilly S, Perrimon N, White EP, Janowitz T. Ferrer M, et al. Among authors: goncalves md. Cell. 2023 Apr 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028. Cell. 2023. PMID: 37116469 Free PMC article. Review.
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, Janowitz T. Ferrer M, et al. Among authors: goncalves md. Cell Metab. 2023 Jul 11;35(7):1147-1162.e7. doi: 10.1016/j.cmet.2023.05.008. Epub 2023 Jun 12. Cell Metab. 2023. PMID: 37311455 Free PMC article.
TIMP1 is an early biomarker for detection and prognosis of lung cancer.
Dantas E, Murthy A, Ahmed T, Ahmed M, Ramsamooj S, Hurd MA, Lam T, Malbari M, Agrusa C, Elemento O, Zhang C, Pappin DJ, McGraw TE, Stiles BM, Altorki NK, Goncalves MD. Dantas E, et al. Among authors: goncalves md. Clin Transl Med. 2023 Oct;13(10):e1391. doi: 10.1002/ctm2.1391. Clin Transl Med. 2023. PMID: 37759102 Free PMC article.
Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.
Langer HT, Ramsamooj S, Dantas E, Murthy A, Ahmed M, Ahmed T, Hwang SK, Grover R, Pozovskiy R, Liang RJ, Queiroz AL, Brown JC, White EP, Janowitz T, Goncalves MD. Langer HT, et al. Among authors: goncalves md. Acta Physiol (Oxf). 2024 Aug;240(8):e14167. doi: 10.1111/apha.14167. Epub 2024 May 23. Acta Physiol (Oxf). 2024. PMID: 38779820
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Goncalves MD, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311302 Free PMC article.
Diet and Cancer Metabolism.
Locasale JW, Goncalves MD, Di Tano M, Burgos-Barragan G. Locasale JW, et al. Among authors: goncalves md. Cold Spring Harb Perspect Med. 2024 Apr 15:a041549. doi: 10.1101/cshperspect.a041549. Online ahead of print. Cold Spring Harb Perspect Med. 2024. PMID: 38621831
143 results