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RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Subbiah V, Sahai V, Maglic D, Bruderek K, Touré BB, Zhao S, Valverde R, O'Hearn PJ, Moustakas DT, Schönherr H, Gerami-Moayed N, Taylor AM, Hudson BM, Houde DJ, Pal D, Foster L, Gunaydin H, Ayaz P, Sharon DA, Goyal L, Schram AM, Kamath S, Sherwin CA, Schmidt-Kittler O, Jen KY, Ricard F, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Casaletto JB. Subbiah V, et al. Among authors: foster l. Cancer Discov. 2023 Sep 6;13(9):2012-2031. doi: 10.1158/2159-8290.CD-23-0475. Cancer Discov. 2023. PMID: 37270847 Free PMC article.
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Schönherr H, Ayaz P, Taylor AM, Casaletto JB, Touré BB, Moustakas DT, Hudson BM, Valverde R, Zhao S, O'Hearn PJ, Foster L, Sharon DA, Garfinkle S, Giordanetto F, Lescarbeau A, Kurukulasuriya R, Gerami-Moayed N, Maglic D, Bruderek K, Naik G, Gunaydin H, Mader MM, Boezio AA, McLean TH, Chen R, Wang Y, Shaw DE, Watters J, Bergstrom DA. Schönherr H, et al. Among authors: foster l. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2317756121. doi: 10.1073/pnas.2317756121. Epub 2024 Feb 1. Proc Natl Acad Sci U S A. 2024. PMID: 38300868 Free PMC article.
Language model-guided anticipation and discovery of unknown metabolites.
Qiang H, Wang F, Lu W, Xing X, Kim H, Merette SAM, Ayres LB, Oler E, AbuSalim JE, Roichman A, Neinast M, Cordova RA, Lee WD, Herbst E, Gupta V, Neff S, Hiebert-Giesbrecht M, Young A, Gautam V, Tian S, Wang B, Röst H, Greiner R, Chen L, Johnston CW, Foster LJ, Shapiro AM, Wishart DS, Rabinowitz JD, Skinnider MA. Qiang H, et al. Among authors: foster lj. bioRxiv [Preprint]. 2024 Nov 15:2024.11.13.623458. doi: 10.1101/2024.11.13.623458. bioRxiv. 2024. PMID: 39605668 Free PMC article. Preprint.
The neonatal Fc receptor is a cellular receptor for human astrovirus.
Ingle H, Molleston JM, Hall PD, Bui D, Wang L, Bhatt KD, Foster L, Antia A, Ding S, Lee S, Fremont DH, Baldridge MT. Ingle H, et al. Among authors: foster l. Nat Microbiol. 2024 Dec;9(12):3321-3331. doi: 10.1038/s41564-024-01855-y. Epub 2024 Nov 22. Nat Microbiol. 2024. PMID: 39578577
The international empirics of management.
Scur D, Ohlmacher S, Van Reenen J, Bennedsen M, Bloom N, Choudhary A, Foster L, Groenewegen J, Grover A, Hardeman S, Iacovone L, Kambayashi R, Laible MC, Lemos R, Li H, Linarello A, Maliranta M, Medvedev D, Meng C, Miles Touya J, Mandirola N, Ohlsbom R, Ohyama A, Patnaik M, Pereira-López M, Sadun R, Senga T, Qian F, Zimmermann F. Scur D, et al. Among authors: foster l. Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2412205121. doi: 10.1073/pnas.2412205121. Epub 2024 Nov 1. Proc Natl Acad Sci U S A. 2024. PMID: 39485796
1,085 results