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Page 1
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, Matthews GM, Barwick BG, Gupta VA, Dupéré-Richer D, Yamano S, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Ishiguro K, Meyers RM, Bryan JG, Dharia NV, Hengeveld PJ, Brüggenthies JB, Tang H, Aguirre AJ, Sievers QL, Ebert BL, Glassner BJ, Ott CJ, Bradner JE, Kwiatkowski NP, Auclair D, Levy J, Keats JJ, Groen RWJ, Gray NS, Culhane AC, McFarland JM, Dempster JM, Licht JD, Boise LH, Hahn WC, Vazquez F, Tsherniak A, Mitsiades CS. de Matos Simoes R, et al. Among authors: sheffer m. Nat Cancer. 2023 May;4(5):754-773. doi: 10.1038/s43018-023-00550-x. Epub 2023 May 26. Nat Cancer. 2023. PMID: 37237081 Free PMC article.
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.
Dufva O, Gandolfi S, Huuhtanen J, Dashevsky O, Duàn H, Saeed K, Klievink J, Nygren P, Bouhlal J, Lahtela J, Näätänen A, Ghimire BR, Hannunen T, Ellonen P, Lähteenmäki H, Rumm P, Theodoropoulos J, Laajala E, Härkönen J, Pölönen P, Heinäniemi M, Hollmén M, Yamano S, Shirasaki R, Barbie DA, Roth JA, Romee R, Sheffer M, Lähdesmäki H, Lee DA, De Matos Simoes R, Kankainen M, Mitsiades CS, Mustjoki S. Dufva O, et al. Among authors: sheffer m. Immunity. 2023 Dec 12;56(12):2816-2835.e13. doi: 10.1016/j.immuni.2023.11.008. Immunity. 2023. PMID: 38091953 Free article.
Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses.
Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Bobilev E, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Liu F, Chen J, Wu CJ, Barbie D, Li J, Romee R. Yang S, et al. Among authors: sheffer m. Nat Biotechnol. 2024 Oct 4. doi: 10.1038/s41587-024-02418-6. Online ahead of print. Nat Biotechnol. 2024. PMID: 39367093
Editorial: Hallmark of cancer: avoiding immune suppression.
Alenzi FQB, Apollonio B, Peng L, Sayour EJ, Sheffer M. Alenzi FQB, et al. Among authors: sheffer m. Front Oncol. 2023 Jun 16;13:1211456. doi: 10.3389/fonc.2023.1211456. eCollection 2023. Front Oncol. 2023. PMID: 37397369 Free PMC article. No abstract available.
CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer.
Tarannum M, Dinh K, Vergara J, Birch G, Abdulhamid YZ, Kaplan IE, Ay O, Maia A, Beaver O, Sheffer M, Shapiro R, Ali AK, Dong H, Ham JD, Bobilev E, James S, Cameron AB, Nguyen QD, Ganapathy S, Chayawatto C, Koreth J, Paweletz CP, Gokhale PC, Barbie DA, Matulonis UA, Soiffer RJ, Ritz J, Porter RL, Chen J, Romee R. Tarannum M, et al. Among authors: sheffer m. Sci Adv. 2024 Jul 12;10(28):eadn0881. doi: 10.1126/sciadv.adn0881. Epub 2024 Jul 12. Sci Adv. 2024. PMID: 38996027 Free PMC article.
Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy.
Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Chen J, Wu CJ, Barbie D, Li J, Romee R. Yang S, et al. Among authors: sheffer m. Res Sq [Preprint]. 2024 Mar 22:rs.3.rs-4031911. doi: 10.21203/rs.3.rs-4031911/v1. Res Sq. 2024. Update in: Nat Biotechnol. 2024 Oct 4. doi: 10.1038/s41587-024-02418-6. PMID: 38562821 Free PMC article. Updated. Preprint.
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1.
Mabe NW, Huang M, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG. Mabe NW, et al. Among authors: sheffer m. Nat Cancer. 2022 Aug;3(8):976-993. doi: 10.1038/s43018-022-00405-x. Epub 2022 Jul 11. Nat Cancer. 2022. PMID: 35817829 Free PMC article.
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse.
Shapiro RM, Birch GC, Hu G, Vergara Cadavid J, Nikiforow S, Baginska J, Ali AK, Tarannum M, Sheffer M, Abdulhamid YZ, Rambaldi B, Arihara Y, Reynolds C, Halpern MS, Rodig SJ, Cullen N, Wolff JO, Pfaff KL, Lane AA, Lindsley RC, Cutler CS, Antin JH, Ho VT, Koreth J, Gooptu M, Kim HT, Malmberg KJ, Wu CJ, Chen J, Soiffer RJ, Ritz J, Romee R. Shapiro RM, et al. Among authors: sheffer m. J Clin Invest. 2022 Jun 1;132(11):e154334. doi: 10.1172/JCI154334. J Clin Invest. 2022. PMID: 35349491 Free PMC article.
51 results