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20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond.
Pascale JV, Wolf A, Kadish Y, Diegisser D, Kulaprathazhe MM, Yemane D, Ali S, Kim N, Baruch DE, Yahaya MAF, Dirice E, Adebesin AM, Falck JR, Schwartzman ML, Garcia V. Pascale JV, et al. Among authors: schwartzman ml. Adv Pharmacol. 2023;97:229-255. doi: 10.1016/bs.apha.2023.01.002. Epub 2023 Feb 24. Adv Pharmacol. 2023. PMID: 37236760 Free PMC article.
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension.
D'Addario CA, Matsumura S, Kitagawa A, Lainer GM, Zhang F, D'silva M, Khan MY, Froogh G, Gruzdev A, Zeldin DC, Schwartzman ML, Gupte SA. D'Addario CA, et al. Among authors: schwartzman ml. Vascul Pharmacol. 2023 Dec;153:107235. doi: 10.1016/j.vph.2023.107235. Epub 2023 Sep 23. Vascul Pharmacol. 2023. PMID: 37742819
Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Schwartzman ML, Sonntag WE, Ungvari Z. Toth P, et al. Among authors: schwartzman ml. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1698-708. doi: 10.1152/ajpheart.00377.2013. Epub 2013 Oct 4. Am J Physiol Heart Circ Physiol. 2013. PMID: 24097425 Free PMC article.
Gpr75-deficient mice are protected from high-fat diet-induced obesity.
Hossain S, Gilani A, Pascale J, Villegas E, Diegisser D, Agostinucci K, Kulaprathazhe MM, Dirice E, Garcia V, Schwartzman ML. Hossain S, et al. Among authors: schwartzman ml. Obesity (Silver Spring). 2023 Apr;31(4):1024-1037. doi: 10.1002/oby.23692. Epub 2023 Feb 28. Obesity (Silver Spring). 2023. PMID: 36854900 Free PMC article.
Neutrophil-Derived Myeloperoxidase and Hypochlorous Acid Critically Contribute to 20-Hydroxyeicosatetraenoic Acid Increases that Drive Postischemic Angiogenesis.
Azcona JA, Tang S, Berry E, Zhang FF, Garvey R, Falck JR, Schwartzman ML, Yi T, Jeitner TM, Guo AM. Azcona JA, et al. Among authors: schwartzman ml. J Pharmacol Exp Ther. 2022 Jun;381(3):204-216. doi: 10.1124/jpet.121.001036. Epub 2022 Mar 19. J Pharmacol Exp Ther. 2022. PMID: 35306474 Free PMC article.
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase.
Agostinucci K, Hutcheson R, Hossain S, Pascale JV, Villegas E, Zhang F, Adebesin AM, Falck JR, Gupte S, Garcia V, Schwartzman ML. Agostinucci K, et al. Among authors: schwartzman ml. J Hypertens. 2022 Mar 1;40(3):498-511. doi: 10.1097/HJH.0000000000003038. J Hypertens. 2022. PMID: 35081581 Free PMC article.
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
Akbari P, Gilani A, Sosina O, Kosmicki JA, Khrimian L, Fang YY, Persaud T, Garcia V, Sun D, Li A, Mbatchou J, Locke AE, Benner C, Verweij N, Lin N, Hossain S, Agostinucci K, Pascale JV, Dirice E, Dunn M; Regeneron Genetics Center; DiscovEHR Collaboration; Kraus WE, Shah SH, Chen YI, Rotter JI, Rader DJ, Melander O, Still CD, Mirshahi T, Carey DJ, Berumen-Campos J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Balasubramanian S, Hawes A, Jones M, Zambrowicz B, Murphy AJ, Paulding C, Coppola G, Overton JD, Reid JG, Shuldiner AR, Cantor M, Kang HM, Abecasis GR, Karalis K, Economides AN, Marchini J, Yancopoulos GD, Sleeman MW, Altarejos J, Della Gatta G, Tapia-Conyer R, Schwartzman ML, Baras A, Ferreira MAR, Lotta LA. Akbari P, et al. Among authors: schwartzman ml. Science. 2021 Jul 2;373(6550):eabf8683. doi: 10.1126/science.abf8683. Science. 2021. PMID: 34210852 Free PMC article.
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
Tarantini S, Balasubramanian P, Yabluchanskiy A, Ashpole NM, Logan S, Kiss T, Ungvari A, Nyúl-Tóth Á, Schwartzman ML, Benyo Z, Sonntag WE, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: schwartzman ml. Geroscience. 2021 Apr;43(2):901-911. doi: 10.1007/s11357-021-00350-0. Epub 2021 Mar 6. Geroscience. 2021. PMID: 33674953 Free PMC article.
156 results