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Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.
Yenerall P, Sung T, Palyada K, Qian J, Arat S, Kumpf SW, Wang SW, Biddle K, Esparza C, Chang S, Scott W, Collette W, Winrow TS, Affolter T, Shirai N, Thibault S, Wang J, Liu L, Bauchmann M, Frey J, Steyn S, Sacaan A, Vitsky A, Ahn Y, Paul T, Lum L, Oyer J, Yang A, Hu W. Yenerall P, et al. Among authors: scott w. Toxicol Sci. 2023 Jun 28;194(1):53-69. doi: 10.1093/toxsci/kfad049. Toxicol Sci. 2023. PMID: 37228089 Free PMC article.
Novel active Trp- and Arg-rich antimicrobial peptides with high solubility and low red blood cell toxicity designed using machine learning tools.
Henson BAB, Li F, Álvarez-Huerta JA, Wedamulla PG, Palacios AV, Scott MRM, Lim DTE, Scott WMH, Villanueva MTL, Ye E, Straus SK. Henson BAB, et al. Among authors: scott wmh. Int J Antimicrob Agents. 2024 Dec 5:107399. doi: 10.1016/j.ijantimicag.2024.107399. Online ahead of print. Int J Antimicrob Agents. 2024. PMID: 39645171 Free article.
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.
Gorman BR, Voloudakis G, Igo RP Jr, Kinzy T, Halladay CW, Bigdeli TB, Zeng B, Venkatesh S, Cooke Bailey JN, Crawford DC, Markianos K, Dong F, Schreiner PA, Zhang W; VA Million Veteran Program; International AMD Genomics Consortium (IAMDGC); Hadi T, Anger MD, Stockwell A, Melles RB, Yin J, Choquet H, Kaye R, Patasova K, Patel PJ, Yaspan BL, Jorgenson E, Hysi PG, Lotery AJ, Gaziano JM, Tsao PS, Fliesler SJ, Sullivan JM, Greenberg PB, Wu WC, Assimes TL, Pyarajan S, Roussos P, Peachey NS, Iyengar SK. Gorman BR, et al. Nat Genet. 2024 Dec;56(12):2659-2671. doi: 10.1038/s41588-024-01764-0. Epub 2024 Dec 2. Nat Genet. 2024. PMID: 39623103
Recurrent DNA nicks drive massive expansions of (GAA)n repeats.
Li L, Scott WS, Khristich AN, Armenia JF, Mirkin SM. Li L, et al. Among authors: scott ws. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2413298121. doi: 10.1073/pnas.2413298121. Epub 2024 Nov 25. Proc Natl Acad Sci U S A. 2024. PMID: 39585990 Free PMC article.
Cerebral amyloid angiopathy impacts neurofibrillary tangle burden and cognition.
Godrich D, Pasteris J, Martin ER, Rundek T, Schellenberg G, Foroud T, Vance JM, Pericak-Vance MA, Cuccaro ML, Scott WK, Kukull W, Montine TJ, Beecham GW. Godrich D, et al. Among authors: scott wk. Brain Commun. 2024 Nov 22;6(6):fcae369. doi: 10.1093/braincomms/fcae369. eCollection 2024. Brain Commun. 2024. PMID: 39584156 Free PMC article.
A multi-region single nucleus transcriptomic atlas of Parkinson's disease.
N M P, Fullard JF, Clarence T, Mathur D, Casey C, Hennigan E, Alvia M, Krause-Massaguer J, Barreda A, Davis DA, Vontell RT, Garamszegi SP, Vance JM, Sang L, Chatigny M, Vismer D, Landin B, Burstein D, Lee D, Voloudakis G, Berretta S, Haroutunian V, Scott WK, Bendl J, Roussos P. N M P, et al. Among authors: scott wk. Sci Data. 2024 Nov 23;11(1):1274. doi: 10.1038/s41597-024-04117-y. Sci Data. 2024. PMID: 39580497 Free PMC article.
Results From a Randomized Trial of Intensive Glucose Management Using CGM Versus Usual Care in Hospitalized Adults With Type 2 Diabetes: The TIGHT Study.
Hirsch IB, Draznin B, Buse JB, Raghinaru D, Spanbauer C, Umpierrez GE, Ullal J, Jones MS, Low Wang CC, Spanakis EK, Chao JH, Sibayan J, Kollman C, Zabala ZE, Moazzami B, Reynolds SL, Ferrara W, Fulghum K, Kass A, Armstrong C, Gilani F, Seggelke S, Churchill J, Monye JO, Choe MY, Scott W, Baran JD, Bais R, Khakpour D, Pasquel FJ, Davis GM, Vellanki P, Kershaw EE, Gligorijevic N, Goley A, Garg A, Alexander B, Matson BC, Diner J, Klein KR, Adair WB, Choksi P, Huang M, Vinh J, Singh LG, Beck RW; TIGHT RCT Study Group. Hirsch IB, et al. Among authors: scott w. Diabetes Care. 2024 Nov 21:dc241779. doi: 10.2337/dc24-1779. Online ahead of print. Diabetes Care. 2024. PMID: 39571106
2,510 results