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Page 1
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Wu Z, Bezwada D, Harris RC, Pan C, Nguyen PT, Faubert B, Cai L, Cai F, Vu HS, Chen H, Sandoval MM, Do D, Gu W, Zhang Y, Ko B, Brooks B, Kelekar S, Zhang Y, Zacharias LG, Oaxaca KC, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Wu Z, et al. Among authors: cai f, cai l. bioRxiv [Preprint]. 2023 May 11:2023.05.11.540429. doi: 10.1101/2023.05.11.540429. bioRxiv. 2023. Update in: Cell Metab. 2024 Jul 2;36(7):1504-1520.e9. doi: 10.1016/j.cmet.2024.05.014. PMID: 37214913 Free PMC article. Updated. Preprint.
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ. Huang F, et al. Among authors: cai f, cai l. Cell Metab. 2018 Sep 4;28(3):369-382.e5. doi: 10.1016/j.cmet.2018.06.005. Epub 2018 Jun 28. Cell Metab. 2018. PMID: 30043754 Free PMC article.
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer.
Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ. Huang F, et al. Among authors: cai f, cai l. J Clin Invest. 2021 Jan 4;131(1):e139929. doi: 10.1172/JCI139929. J Clin Invest. 2021. PMID: 33079728 Free PMC article.
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. Kim J, et al. Among authors: cai f, cai l. Nat Metab. 2020 Dec;2(12):1401-1412. doi: 10.1038/s42255-020-00316-0. Epub 2020 Nov 30. Nat Metab. 2020. PMID: 33257855 Free PMC article.
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth.
Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA 3rd, DeBerardinis RJ, Hoxhaj G. Tran DH, et al. Among authors: cai f. Nat Metab. 2021 Apr;3(4):571-585. doi: 10.1038/s42255-021-00374-y. Epub 2021 Apr 8. Nat Metab. 2021. PMID: 33833463 Free PMC article.
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Soflaee MH, et al. Among authors: cai f. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. Nat Commun. 2022. PMID: 35577785 Free PMC article.
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.
Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ. Kaushik AK, et al. Among authors: cai f. Sci Adv. 2022 Dec 16;8(50):eabp8293. doi: 10.1126/sciadv.abp8293. Epub 2022 Dec 16. Sci Adv. 2022. PMID: 36525494 Free PMC article.
Mitochondrial metabolism in primary and metastatic human kidney cancers.
Bezwada D, Lesner NP, Brooks B, Vu HS, Wu Z, Cai L, Kasitinon S, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, Sudderth J, Dumesnil D, House S, Rosales T, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Margulis V, DeBerardinis RJ. Bezwada D, et al. Among authors: cai f, cai l. bioRxiv [Preprint]. 2023 Feb 7:2023.02.06.527285. doi: 10.1101/2023.02.06.527285. bioRxiv. 2023. Update in: Nature. 2024 Sep;633(8031):923-931. doi: 10.1038/s41586-024-07812-3. PMID: 36798172 Free PMC article. Updated. Preprint.
1,564 results