Lepesheva GI - Search Results

1

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.

McCarty KD, Sullivan ME, Tateishi Y, Hargrove TY, Lepesheva GI, Guengerich FP. McCarty KD, et al. Among authors: lepesheva gi. J Biol Chem. 2023 Jul;299(7):104841. doi: 10.1016/j.jbc.2023.104841. Epub 2023 May 18. J Biol Chem. 2023. PMID: 37209823 Free PMC article.

2

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.

Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. Lepesheva GI, et al. J Biol Chem. 2006 Feb 10;281(6):3577-85. doi: 10.1074/jbc.M510317200. Epub 2005 Nov 30. J Biol Chem. 2006. PMID: 16321980 Free article.

3

Biodiversity of CYP51 in trypanosomes.

Lepesheva GI, Hargrove TY, Ott RD, Nes WD, Waterman MR. Lepesheva GI, et al. Biochem Soc Trans. 2006 Dec;34(Pt 6):1161-4. doi: 10.1042/BST0341161. Biochem Soc Trans. 2006. PMID: 17073776

4

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.

Lepesheva GI, Ott RD, Hargrove TY, Kleshchenko YY, Schuster I, Nes WD, Hill GC, Villalta F, Waterman MR. Lepesheva GI, et al. Chem Biol. 2007 Nov;14(11):1283-93. doi: 10.1016/j.chembiol.2007.10.011. Chem Biol. 2007. PMID: 18022567 Free PMC article.

5

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI. Konkle ME, et al. Among authors: lepesheva gi. J Med Chem. 2009 May 14;52(9):2846-53. doi: 10.1021/jm801643b. J Med Chem. 2009. PMID: 19354253 Free PMC article.

6

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Lepesheva GI, et al. J Biol Chem. 2010 Jan 15;285(3):1773-80. doi: 10.1074/jbc.M109.067470. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923211 Free PMC article.

7

Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.

Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR. Lepesheva GI, et al. J Biol Chem. 2010 Aug 13;285(33):25582-90. doi: 10.1074/jbc.M110.133215. Epub 2010 Jun 8. J Biol Chem. 2010. PMID: 20530488 Free PMC article.

8

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

Hargrove TY, Wawrzak Z, Liu J, Nes WD, Waterman MR, Lepesheva GI. Hargrove TY, et al. Among authors: lepesheva gi. J Biol Chem. 2011 Jul 29;286(30):26838-48. doi: 10.1074/jbc.M111.237099. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21632531 Free PMC article.

9

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.

Hargrove TY, Wawrzak Z, Liu J, Waterman MR, Nes WD, Lepesheva GI. Hargrove TY, et al. Among authors: lepesheva gi. J Lipid Res. 2012 Feb;53(2):311-20. doi: 10.1194/jlr.M021865. Epub 2011 Nov 30. J Lipid Res. 2012. PMID: 22135275 Free PMC article.

10

VNI cures acute and chronic experimental Chagas disease.

Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI. Villalta F, et al. Among authors: lepesheva gi. J Infect Dis. 2013 Aug 1;208(3):504-11. doi: 10.1093/infdis/jit042. Epub 2013 Jan 31. J Infect Dis. 2013. PMID: 23372180 Free PMC article.

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