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Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells.
Kojima M, Suzuki K, Takeshita M, Ohyagi M, Iizuka M, Yamane H, Koga K, Kouro T, Kassai Y, Yoshihara T, Adachi R, Hashikami K, Ota Y, Yoshimoto K, Kaneko Y, Morita R, Yoshimura A, Takeuchi T. Kojima M, et al. Among authors: ohyagi m. Commun Biol. 2023 May 9;6(1):500. doi: 10.1038/s42003-023-04874-3. Commun Biol. 2023. PMID: 37161050 Free PMC article.
T cells in the brain inflammation.
Yoshimura A, Ohyagi M, Ito M. Yoshimura A, et al. Among authors: ohyagi m. Adv Immunol. 2023;157:29-58. doi: 10.1016/bs.ai.2022.10.001. Epub 2022 Nov 24. Adv Immunol. 2023. PMID: 37061287 Review.
Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant.
Mise-Omata S, Ikeda M, Takeshita M, Uwamino Y, Wakui M, Arai T, Yoshifuji A, Murano K, Siomi H, Nakagawara K, Ohyagi M, Ando M, Hasegawa N, Saya H, Murata M, Fukunaga K, Namkoong H, Lu X, Yamasaki S, Yoshimura A. Mise-Omata S, et al. Among authors: ohyagi m. J Immunol. 2022 Dec 1;209(11):2104-2113. doi: 10.4049/jimmunol.2200525. J Immunol. 2022. PMID: 36426984
Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve.
Kaburagi H, Nagata T, Enomoto M, Hirai T, Ohyagi M, Ihara K, Yoshida-Tanaka K, Ebihara S, Asada K, Yokoyama H, Okawa A, Yokota T. Kaburagi H, et al. Among authors: ohyagi m. Mol Ther Nucleic Acids. 2022 May 6;28:910-919. doi: 10.1016/j.omtn.2022.05.006. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35694210 Free PMC article.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T. Nagata T, et al. Among authors: ohyagi m. Nat Biotechnol. 2021 Dec;39(12):1529-1536. doi: 10.1038/s41587-021-00972-x. Epub 2021 Aug 12. Nat Biotechnol. 2021. PMID: 34385691
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