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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.
Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, Santana JF, Miklavcic WR, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. Mullen NJ, et al. Among authors: mehla k. bioRxiv [Preprint]. 2024 Jan 13:2023.04.03.535399. doi: 10.1101/2023.04.03.535399. bioRxiv. 2024. Update in: Elife. 2024 Jul 08;12:RP87292. doi: 10.7554/eLife.87292 PMID: 37066260 Free PMC article. Updated. Preprint.
MicroRNAs in pancreatic cancer metabolism.
Singh PK, Brand RE, Mehla K. Singh PK, et al. Among authors: mehla k. Nat Rev Gastroenterol Hepatol. 2012 Apr 17;9(6):334-44. doi: 10.1038/nrgastro.2012.63. Nat Rev Gastroenterol Hepatol. 2012. PMID: 22508159 Free PMC article. Review.
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.
Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK. Chaika NV, et al. Among authors: mehla k. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13787-92. doi: 10.1073/pnas.1203339109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869720 Free PMC article.
MUC1: a novel metabolic master regulator.
Mehla K, Singh PK. Mehla K, et al. Biochim Biophys Acta. 2014 Apr;1845(2):126-35. doi: 10.1016/j.bbcan.2014.01.001. Epub 2014 Jan 11. Biochim Biophys Acta. 2014. PMID: 24418575 Free PMC article. Review.
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. Shukla SK, et al. Among authors: mehla k. Cancer Cell. 2017 Jul 10;32(1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. Cancer Cell. 2017. PMID: 28697344 Free PMC article.
52 results