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Page 1
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.
Chardon FM, McDiarmid TA, Page NF, Daza RM, Martin BK, Domcke S, Regalado SG, Lalanne JB, Calderon D, Li X, Starita LM, Sanders SJ, Ahituv N, Shendure J. Chardon FM, et al. Among authors: domcke s. Nat Commun. 2024 Sep 18;15(1):8209. doi: 10.1038/s41467-024-52490-4. Nat Commun. 2024. PMID: 39294132 Free PMC article.
Noncoding variants are a rare cause of recessive developmental disorders in trans with coding variants.
Lord J, Oquendo CJ, Wai HA, Holloway JG, Martin-Geary A, Blakes AJM, Arciero E, Domcke S, Childs AM, Low K, Rankin J; Genomics England Research Consortium; Baralle D, Martin HC, Whiffin N. Lord J, et al. Among authors: domcke s. Genet Med. 2024 Sep 3;26(12):101249. doi: 10.1016/j.gim.2024.101249. Online ahead of print. Genet Med. 2024. PMID: 39243181 Free article.
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy.
McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C. McFaline-Figueroa JL, et al. Among authors: domcke s. Cell Genom. 2024 Feb 14;4(2):100487. doi: 10.1016/j.xgen.2023.100487. Epub 2024 Jan 25. Cell Genom. 2024. PMID: 38278156 Free PMC article.
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy.
McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C. McFaline-Figueroa JL, et al. Among authors: domcke s. bioRxiv [Preprint]. 2023 Jun 14:2023.03.10.531983. doi: 10.1101/2023.03.10.531983. bioRxiv. 2023. Update in: Cell Genom. 2024 Feb 14;4(2):100487. doi: 10.1016/j.xgen.2023.100487 PMID: 37398090 Free PMC article. Updated. Preprint.
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.
Chardon FM, McDiarmid TA, Page NF, Daza RM, Martin B, Domcke S, Regalado SG, Lalanne JB, Calderon D, Li X, Starita LM, Sanders SJ, Ahituv N, Shendure J. Chardon FM, et al. Among authors: domcke s. bioRxiv [Preprint]. 2024 Apr 30:2023.03.28.534017. doi: 10.1101/2023.03.28.534017. bioRxiv. 2024. Update in: Nat Commun. 2024 Sep 18;15(1):8209. doi: 10.1038/s41467-024-52490-4 PMID: 37034704 Free PMC article. Updated. Preprint.
DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions.
Butz S, Schmolka N, Karemaker ID, Villaseñor R, Schwarz I, Domcke S, Uijttewaal ECH, Jude J, Lienert F, Krebs AR, de Wagenaar NP, Bao X, Zuber J, Elling U, Schübeler D, Baubec T. Butz S, et al. Among authors: domcke s. Nat Genet. 2022 Nov;54(11):1702-1710. doi: 10.1038/s41588-022-01210-z. Epub 2022 Nov 4. Nat Genet. 2022. PMID: 36333500 Free PMC article.
A time-resolved, multi-symbol molecular recorder via sequential genome editing.
Choi J, Chen W, Minkina A, Chardon FM, Suiter CC, Regalado SG, Domcke S, Hamazaki N, Lee C, Martin B, Daza RM, Shendure J. Choi J, et al. Among authors: domcke s. Nature. 2022 Aug;608(7921):98-107. doi: 10.1038/s41586-022-04922-8. Epub 2022 Jul 6. Nature. 2022. PMID: 35794474 Free PMC article.
15 results