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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Clark JC, Martin EM, Morán LA, Di Y, Wang X, Zuidscherwoude M, Brown HC, Kavanagh DM, Hummert J, Eble JA, Nieswandt B, Stegner D, Pollitt AY, Herten DP, Tomlinson MG, García A, Watson SP. Clark JC, et al. Among authors: pollitt ay. Commun Biol. 2023 Apr 7;6(1):376. doi: 10.1038/s42003-023-04766-6. Commun Biol. 2023. PMID: 37029319 Free PMC article.
Renal cells activate the platelet receptor CLEC-2 through podoplanin.
Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA. Christou CM, et al. Among authors: pollitt ay. Biochem J. 2008 Apr 1;411(1):133-40. doi: 10.1042/BJ20071216. Biochem J. 2008. PMID: 18215137 Free PMC article.
CLEC-2 activates Syk through dimerization.
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. Hughes CE, et al. Among authors: pollitt ay. Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12. Blood. 2010. PMID: 20154219 Free PMC article.
GPVI and CLEC-2 in hemostasis and vascular integrity.
Watson SP, Herbert JM, Pollitt AY. Watson SP, et al. Among authors: pollitt ay. J Thromb Haemost. 2010 Jul;8(7):1456-67. doi: 10.1111/j.1538-7836.2010.03875.x. Epub 2010 Mar 25. J Thromb Haemost. 2010. PMID: 20345705 Free article. Review.
CLEC-2 is not required for platelet aggregation at arteriolar shear.
Hughes CE, Navarro-Núñez L, Finney BA, Mourão-Sá D, Pollitt AY, Watson SP. Hughes CE, et al. Among authors: pollitt ay. J Thromb Haemost. 2010 Oct;8(10):2328-2332. doi: 10.1111/j.1538-7836.2010.04006.x. J Thromb Haemost. 2010. PMID: 20695981 Free PMC article. No abstract available.
35 results